Results 101 to 110 of about 13,643,061 (311)

Mathematical modelling and optimal control of constrained systems

, 2009
This thesis is concerned with mathematical modelling and optimal control of constrained systems. Each of the systems under consideration is a system that can be controlled by one of the variables, and this control is subject to constraints.
Pitcher, Ashley Brooke
core   +1 more source

Construction of D-optimal saturated designs for main effects and F1-second-order interactions in the presence of a free factor

Statistical Theory and Related Fields
The allocation of resources in a [Formula: see text]-factorial experiment is crucial when the experimental resources are limited. In practice, when resources are limited, it is common for investigators to use all the information at their disposal to ...
Francois K. Domagni, Yujia Zhang, A. S. Hedayat   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

On Backstops and Boomerangs: Environmental R&D under Technological Uncertainty [PDF]

The literature on environmental R&D frequently studies innovation as a two-stage process, with a single R&D event leading from a conventional polluting technology to a perfectly clean backstop.
Grischa Perino, Timo Goeschl
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Cohomology of D-complex manifolds

, 2012
In order to look for a well-behaved counterpart to Dolbeault cohomology in D-complex geometry, we study the de Rham cohomology of an almost D-complex manifold and its subgroups made up of the classes admitting invariant, respectively anti-invariant ...
Daniele Angella, Rossi, Federico Alberto, Federico Alberto Rossi, Angella, Daniele, Angella, D   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Optimal Control Design for Multiterminal HVDC [PDF]

, 2013
This thesis proposes an optimal-control based design for distributed frequency control in multi-terminal high voltage direct current (MTDC) systems.
de Courreges d'Ustou, Benoit
core  

Some Properties of Multiresponse D-Optimal Designs

Journal of Mathematical Analysis and Applications, 1994
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source