Results 121 to 130 of about 13,643,061 (311)
Efficient D-optimal designs under multiplicative heteroscedasticity. [PDF]
In optimum design theory designs are constructed that maximize the information on the unknown parameters of the response function. The major part deals with designs optimal for response function estimation under the assumption of homoscedasticity.
Goos, Peter +2 more
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Журнал Белорусского государственного университета: Математика, информатика, 2018 In article the problem of construction of exact D-optimal designs of experiments for linear multiple regression in a case when variance of errors of observations depend on a point in which is made is investigated. The class functions describing change of
Valery P. Kirlitsa
doaj
D-Optimal Design and Development of a Koumine-Loaded Microemulsion for Rheumatoid Arthritis Treatment: In vivo and in vitro Evaluation. [PDF]
Int J Nanomedicine, 2023 Hu Q +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Bayesian and maximin optimal designs for heteroscedastic regression models [PDF]
The problem of constructing standardized maximin D-optimal designs for weighted polynomial regression models is addressed. In particular it is shown that, by following the broad approach to the construction of maximin designs introduced recently by Dette,
Dette, Holger +2 more
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Optimization of a Mucoadhesive Vaginal Gel Containing Clotrimazole Using a D-Optimal Experimental Design and Multivariate Analysis. [PDF]
Polymers (Basel), 2023 Dinte E +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Anytime Optimal Coalition Structure Generation
, 2007 Forming effective coalitions is a major research challenge in the field of multi-agent systems. Central to this endeavour is the problem of determining the best groups of agents to select to achieve some goal.
Viet Dung Dang +12 more
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
International Schumpeterian Competition and Optimal R&D subsidies [PDF]
This paper studies the welfare effects of international competition in the market for innovations, and analyzes how competition affects the costs and the benefits of cooperative and non-cooperative R&D subsidies.
Giammario Impullitti
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