Results 131 to 140 of about 13,643,061 (311)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Cost reduction, competitive pressure and firms' optimal R&D strategies in a duopolistic industry

open access: yes, 1997
This paper deals with a duopolistic industry where firms are engaged in cost-reducing R&D activity in order to maximize their market shares. Firms' R&D competition is characterized as a dynamic noncooperative feedback game where the optimal strategies ...
Campisi, D   +8 more
core  

Optimal spatial field control for controlled release ‡

open access: yes, 2020
SUMMARY Most distributed parameter control problems involve manipulation within the spatial domain. Such problems arise in a variety of applications including epidemiology, tissue engineering, and cancer treatment.
Optim, Optimal
core  

Singularities of optimal control problems on some 6-D lie groups

open access: yes, 2007
This paper considers the motion planning problem for oriented vehicles travelling at unit speed in a 3-D space. A Lie group formulation arises naturally and the vehicles are modeled as kinematic control systems with drift defined on the orthonormal frame
Biggs, James   +7 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

D-optimal designs for pharmacokinetic and combined pharmacokinetic pharmacodynamic models.

open access: yes, 2006
D-optimal designs for pharmacokinetic and combined pharmacokinetic pharmacodynamic ...
Xin. Fang (7990493)
core  

Localization and Constrained Non-Linear Optimal Control in Autonomous Systems [PDF]

open access: yes, 2010
Path planning for an autonomous vehicle in a dynamic environment is a challenging problem particularly if the vehicle has to utilize its complete maneuvering abilities, perceive its environment with a high degree of accuracy and react to unsafe ...
Viswanathan, Anuradha
core  

Home - About - Disclaimer - Privacy