Results 111 to 120 of about 13,643,061 (311)

Optimal Maintenance Planning in Novel Settings [PDF]

, 2017
In this dissertation work, we focus on optimal planning of maintenance activities in several novel settings.\ud \ud First, we consider a maintenance optimization model for a system with periodic preventive maintenance (PM), and periodic imperfect ...
He, Kai
core  

Prevalence of vitamin D deficiency in the Arab countries: a systematic review and meta-analysis

Discover Public Health
Background There are currently 22 Arab states, yet data on the overall prevalence of vitamin D deficiency (VDD) in these countries remain limited. Objectives The objective of this study was to examine the prevalence of VDD among healthy adults in the ...
Adla B. Hassan, Saja H. Alamien, Namaa A. Khalil, Samah H. Alamien, Rowida M. Hamid, Aishah J. Altourah, Balqees H. Hasan, Latifa A. Mahmoud, Yasin I. Tayem, Haitham Jahrami   +9 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The optimal design of an experiment with blocks of size two for quadratic regression on one variable. [PDF]

Exact D-optimal designs are derived for an optometry experiment for the estimation of a quadratic polynomial in one explanatory variable. Two observations are made for each subject participating in the experiment, such that each subject serves as a block
Goos, Peter, Vandebroek, Martina
core  

Exploring optimal supplementation for people with vitamin D deficiency

Osteoporosis and Sarcopenia, 2023
Han Seok Choi
doaj   +1 more source

The Use of D-Optimal Mixture Design in Optimizing Formulation of a Nutraceutical Hard Candy. [PDF]

Int J Food Sci, 2023
Souiy Z, Amri Z, Sharif H, Souiy A, Cheraief I, Hamden K, Hamden K, Hammami M.   +7 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Exact optimal designs for weighted least squares analysis with correlated errors [PDF]

In the common linear and quadratic regression model with an autoregressive error structure exact D-optimal designs for weighted least squares analysis are determined.
Kunert, Joachim, Dette, Holger
core  

Reduction in the Estimation Error in Load Inversion Problems: Application to an Aerostructure

Engineering Proceedings
The present work focuses on the inverse identification of loads acting on wing-like geometries, through strain measurements. These loads are considered quasi-static and considered acting at discrete stations across the span of the wing.
George Panou, Sotiris G. Panagiotopoulos, Konstantinos Anyfantis   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source