Results 91 to 100 of about 3,379,244 (276)
Finding High-Dimensional D-OptimalDesigns for Logistic Models via Differential Evolution [PDF]
, 2020 D-optimal designs are frequently used in controlled experiments to obtain the most accurateestimate of model parameters at minimal cost. Finding them can be a challenging task, especially whenthere are many factors in a nonlinear model.
Tan, Kay Chen +3 more
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Recent developments in D-optimal designs
Communications in Statistics - Theory and Methods, 2018 In the paper, some issues concerned with the determining spring balance weighing designs satisfying the criterion of D-optimality under the assumption measurement errors are uncorrelated and they have the same variances are discussed. In addition, highly D-efficient spring balance weighing designs are also considered.
B. Ceranka, M. Graczyk
openaire +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Efficient conjoint choice designs in the presence of respondent heterogeneity. [PDF]
The authors propose a fast and efficient algorithm for constructing D-optimal conjoint choice designs for mixed logit models in the presence of respondent heterogeneity.
Goos, Peter +2 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Saponification of Jatropha curcas Seed Oil: Optimization by D-Optimal Design
International Journal of Chemical Engineering, 2012 In this study, the effects of ethanolic KOH concentration, reaction temperature, and reaction time to free fatty acid (FFA) percentage were investigated.
Jumat Salimon +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Optimization, physical-chemical evaluation and healing activity of chitosan ointment [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2019 Context: Chitosan has received attention as a functional, sustainably renewable, nontoxic and biodegradable biopolymer for pharmaceutical applications such as healing agent.
Dania Pérez +5 more
doaj