Results 61 to 70 of about 3,379,244 (276)
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
REGULAR D-OPTIMAL SPRING BALANCE WEIGHING DESIGNS: CONSTRUCTION
Spring balance weighing design there is the model of experiment in that the result of experiment we can present as linear combination of unknown measurements of objects with factors of this combination equal to zero or one.
Bronisław Ceranka
doaj
Some Properties of Multiresponse D-Optimal Designs
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
$T$-optimal discriminating designs for Fourier regression models [PDF]
In this paper we consider the problem of constructing $T$-optimal discriminating designs for Fourier regression models. We provide explicit solutions of the optimal design problem for discriminating between two Fourier regression models, which differ by ...
Dette, Holger +2 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Maximal determinants and saturated D-optimal designs of orders 19 and 37 [PDF]
A saturated D-optimal design is a {+1,-1} square matrix of given order with maximal determinant. We search for saturated D-optimal designs of orders 19 and 37, and find that known matrices due to Smith, Cohn, Orrick and Solomon are optimal.
Brent, Richard P. +3 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Nutritional and sensory quality of wheat bread supplemented with cassava and soybean flours
Sixteen composite flours were prepared using D-optimal constrained mixture design within a range of wheat 40–80%, cassava 10–30% and soybean 10–30% to optimize bread nutrient quality and sensory acceptability.
Haimanot H. Ayele +3 more
doaj +1 more source
RANCANGAN D-OPTIMAL UNTUK MODEL EKSPONENSIAL GENERAL
Exponential model is widely used in biology, chemistry, pharmacokinetics and microbiology. D-optimal criteria is criteria with the purpuse to minimize the variance of the estimator of parameters in the model.
Tatik Widiharih +2 more
doaj +1 more source

