Results 81 to 90 of about 3,379,244 (276)
Exact optimal designs for weighted least squares analysis with correlated errors [PDF]
In the common linear and quadratic regression model with an autoregressive error structure exact D-optimal designs for weighted least squares analysis are determined.
Dette, Holger, Kunert, Joachim
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Design of a new prebiotic beef snack formulation by D-optimal mixture design
Journal of Agriculture and Food ResearchThis study optimized a prebiotic beef snack formulation using inulin, wheat flour, and corn flour at a 12 % ratio via the D-optimal mixture design. Samples were analyzed for physicochemical and sensory properties.
Hassan Dadkhah +8 more
doaj +1 more source
Drug Delivery, 2017 Agomelatine is a new antidepressant having very low oral drug bioavailability less than 5% due to being liable to extensive hepatic 1st pass effect. This study aimed to deliver agomelatine by transdermal route through formulation and optimization of ...
Mayada Said +3 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
On the number of D-optimal designs
Journal of Combinatorial Theory, Series A, 1994 The main result of the paper is the theorem: For \(n=18\), there are precisely three essentially different matrices with elements \(\pm 1\) having the maximum determinant. Only one of these is of the circulant type, but all are of the skew type. This means that there are three \(D\)-optimal designs for \(n=18\).
openaire +2 more sources
Optimal designs for free knot least squares splines [PDF]
In this paper D-optimal designs for free knot least squares spline estimation are investigated. In contrast to most of the literature on optimal design for spline regression models it is assumed that the knots of the spline are also estimated from the ...
Dette, Holger +2 more
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Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Bayesian sequential D-D optimal model-robust designs. [PDF]
Alphabetic optimal design theory assumes that the model for which the optimal design is derived is usually known. However in real-life applications, this assumption may not be credible, as models are rarely known in advance.
Ruggoo, A, Vandebroek, Martina
core
Standardized maximim D-optimal designs for enzyme kineticinhibition models [PDF]
, 2017 Locally optimal designs for nonlinear models require a single set of nominal values for the unknown parameters.An alternative is the maximin approach that allows the user to specify a range of values for each parameter ofinterest.
Chen, Ping-Yang +3 more
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