Results 141 to 150 of about 13,560,800 (313)

UAV Path Optimization for Angle-Only Self-Localization and Target Tracking Based on the Bayesian Fisher Information Matrix

open access: yesSensors
In this paper, new path optimization algorithms are developed for uncrewed aerial vehicle (UAV) self-localization and target tracking, exploiting beacon (landmark) bearings and angle-of-arrival (AOA) measurements from a manoeuvring target. To account for
Kutluyil Dogancay, Hatem Hmam
doaj   +1 more source

Sequences Converging to $D$-Optimal Designs of Experiments

open access: yesThe Annals of Statistics, 1973
Fedorov (Theory of Optimal Experiments (1972)) gives a sequence of designs converging to a $D$-optimal design. Several modifications of that sequence are given to improve the speed of convergence. The analogous sequence for estimating some of the parameters is shown to converge to a $D$-optimal design, whether or not all the parameters are estimable ...
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Measuring tax efficiency: A tax optimality index

open access: yes, 2006
This paper introduces an index of tax optimality that measures the distance of some current tax structure from the optimal tax structure in the presence of public goods.
Raimondos-Møller, Pascalis   +1 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Object Agreement in Palauan: Specificity, Humanness, Economy, and Optimality

open access: yes, 1995
Complex conditions on object agreement and preposition insertion in Palauan, conditioned by aspect, specificity, number, and humanness, are shown to follow from a modified version of Diesing's Mapping Hypothesis interacting with (ranked with respect to ...

core  

Coordination in Optimality Theory

open access: yes, 2005
This dissertation provides an analysis of coordination within a restricted version of Optimality Theory (OT), operating exclusively with alignment and faithfulness constraints.
Gáspár, Miklós
core   +1 more source

Estimation of Unknown Object Measures in a Chemical Weighing Design with Correlated Errors

open access: yesActa Universitatis Lodziensis. Folia Oeconomica
In this paper, some problems that concern the determining of unknown measurements of objects in the model of a chemical balance weighing design are presented.
Małgorzata Graczyk, Bronisław Ceranka
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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