Results 131 to 140 of about 10,339,939 (316)

Optimality Theory and Minimalism: A Possible Convergence?

open access: yes, 2006
This issue of Linguistics in Potsdam contains a number of papers that grew out of the workshop Descriptive and Empirical Adequacy in Linguistics held in Berlin on December 17-19 December, 2005.

core  

Prosodic domains and ambisyllabicity in optimality theory

open access: yes, 1997
Selkirk 1984, 1986, Nespor & Vogel 1986 and others independently argue that PrWd structure is built from morphological structure. In Optimality Theory, Generalized Alignment (McCarthy & Prince 1993b) has been successful in encoding the close relationship
Hong, Soonhyun
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Inference and Optimal Design on Partially Accelerated Life Tests for the Power Half-Logistic Distribution Under Adaptive Type II Progressive Censoring

open access: yesMathematics
This study explores accelerated life tests to examine the durability of highly reliable products. These tests involve applying higher stress levels, such as increased temperature, voltage, or pressure, that cause early failures.
Hanan Haj Ahmad, Mahmoud M. El-Awady
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

On the Principle of Optimality for Nonstationary Deterministic Dynamic Programming [PDF]

open access: yes
This note studies a general nonstationary infinite-horizon optimization problem in discrete time. We allow the state space in each period to be an arbitrary set, and the return function in each period to be unbounded.
Takashi Kamihigashi
core  

Coordination in Optimality Theory

open access: yes, 2005
This dissertation provides an analysis of coordination within a restricted version of Optimality Theory (OT), operating exclusively with alignment and faithfulness constraints.
Gáspár, Miklós
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

English loanwords in Thai and Optimality Theory

open access: yes, 2007
This study focuses on English loanwords in Thai, particularly the treatment of consonants in different environments, namely onset/coda simplification, laryngeal features, medial consonants, and liquid alternation, within the framework of Optimality ...

core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy