Results 111 to 120 of about 20,921 (290)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
D-optimal plans for variable selection in data bases [PDF]
This paper is based on an article of Pumplün et al. (2005a) that investigates the use of Design of Experiments in data bases in order to select variables that are relevant for classification in situations where a sufficient number of measurements of the ...
Schiffner, Julia, Weihs, Claus
core
Improving D-Optimality in Nonlinear Situations
, 2021 Experimental designs based on the classical D-optimal criterion minimize the volume of the linear-approximation inference regions for the parameters using local sensitivity coefficients. For nonlinear models, these designs can be unreliable because the linearized inference regions do not always provide a true indication of the exact parameter inference
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Bayesian sequential D-D optimal model-robust designs. [PDF]
Alphabetic optimal design theory assumes that the model for which the optimal design is derived is usually known. However in real-life applications, this assumption may not be credible, as models are rarely known in advance.
Ruggoo, A, Vandebroek, Martina
core
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
A D-optimal design of order 102
Discrete Mathematics, 1992 The author describes a computer search to construct a \(D\)-optimal design of order 102.
openaire +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
MathematicsThis study explores accelerated life tests to examine the durability of highly reliable products. These tests involve applying higher stress levels, such as increased temperature, voltage, or pressure, that cause early failures.
Hanan Haj Ahmad, Mahmoud M. El-Awady
doaj +1 more source