Results 111 to 120 of about 13,560,800 (313)

Morphologically Governed Accent in Optimality Theory

open access: yes, 1999
This dissertation examines the influence of morphological factors on stress and pitch accent. Two basic types are recognized. In root-controlled accent, inherent accent in a root overrides inherent affix accent; as a result, affixal accent is only ...
Alderete, John D.
core   +1 more source

Multicriteria Optimization Model to Generate on‐DEM Optimal Channel Networks

open access: yesWater Resources Research, 2018
The theory of optimal channel networks (OCNs) explains the existence of self‐similarities in river networks by multiple optimality principles, namely, (i) the minimum energy expenditure in any link, (ii) the equal energy expenditure per unit area of ...
Simone Bizzi   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

mic Efficiency and Pareto Optimality in a Stochastic OLG Model with Production and Social Security [PDF]

open access: yes
We analyze the interaction between risk sharing and capital accumulation in a stochastic OLG model with production. We give a complete characterization of interim Pareto optimality.
Marcus Hagedorn   +2 more
core  

The Typology of Rounding Harmony: An Optimality Theoretic Approach

open access: yes, 1995
This thesis explores the typology of rounding harmony within the framework of optimality theory. A systematic survey of the range of attested rounding harmony phenomena is presented and an analysis of this typology is proposed which invokes constraints ...
Kaun, Abigail Rhoades
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

First order optimality condition for constrained set-valued optimization [PDF]

open access: yes
A constrained optimization problem with set-valued data is considered. Different kind of solutions are defined for such a problem. We recall weak minimizer, efficient minimizer and proper minimizer.
Rocca Matteo   +2 more
core  

Efficient Greedy Algorithm for Multi-Objective Sensor Placement Optimization

open access: yesEngineered Science
The sensor placement problem is a complex combinatorial optimization challenge, where greedy selection provides performance guarantees for submodular objective functions, yielding suboptimal yet efficient solutions. Multi-objective optimization addresses
Wangchun Zhang   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Evaluating the complexity of optimality theory

open access: yes, 2009
Idsardi (2006) claims that Optimality Theory (OT; Prince and Smolensky (1993/2004) is "in general computationally intractable" on the basis of a proof adapted from Eisner (1997). We take issue with this conclusion on two grounds.

core  

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