Results 101 to 110 of about 20,921 (290)
Subsampling Algorithms for Irregularly Spaced Autoregressive Models
AlgorithmsWith the exponential growth of data across diverse fields, applying conventional statistical methods directly to large-scale datasets has become computationally infeasible.
Jiaqi Liu +3 more
doaj +1 more source
Semi-bayesian D-optimal designs and estimation procedures for mean and variance functions. [PDF]
Semi-Bayesian D-optimal designs for fitting mean and variance functions are derived for some prior distributions on the variance function parameters. The impact of the mean of the prior and of the uncertainty about this mean is analyzed.
Goos, Peter, Vandebroek, Martina
core
On the number of D-optimal designs
Journal of Combinatorial Theory, Series A, 1994 The main result of the paper is the theorem: For \(n=18\), there are precisely three essentially different matrices with elements \(\pm 1\) having the maximum determinant. Only one of these is of the circulant type, but all are of the skew type. This means that there are three \(D\)-optimal designs for \(n=18\).
openaire +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Multicriteria Optimization Model to Generate on‐DEM Optimal Channel Networks
Water Resources Research, 2018 The theory of optimal channel networks (OCNs) explains the existence of self‐similarities in river networks by multiple optimality principles, namely, (i) the minimum energy expenditure in any link, (ii) the equal energy expenditure per unit area of ...
Simone Bizzi +4 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Recent developments in D-optimal designs
Communications in Statistics - Theory and Methods, 2018 In the paper, some issues concerned with the determining spring balance weighing designs satisfying the criterion of D-optimality under the assumption measurement errors are uncorrelated and they have the same variances are discussed. In addition, highly D-efficient spring balance weighing designs are also considered.
B. Ceranka, M. Graczyk
openaire +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source