Results 81 to 90 of about 10,339,939 (316)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

On optimality in intergenerational risk sharing [PDF]

open access: yes
This paper defines and studies optimality in a dynamic stochastic economy with finitely lived agents, and investigates the optimality properties of an equilibrium with or without sequentially complete markets.
Gabrielle Demange
core  

Optimality and Wh-Extraction

open access: yes, 1995
In this paper, we propose to start addressing the issues outlined above from the perspective of Optimality Theory (OT, Prince and Smolensky, 1993) and test the hypothesis that different patterns of extractability across languages result from different ...
Raymond, William   +4 more
core   +1 more source

English stress preservation and Stratal Optimality Theory [PDF]

open access: yes, 2007
Since Chomsky & Halle (1968), English stress preservation has been important in generative discussions of morphophonological interaction. This thesis carries out empirical investigations into English stress preservation, and uses their results to argue ...
Collie, Sarah
core   +1 more source

A Highly D‑efficient Spring Balance Weighing Design for an Even Number of Objects

open access: yesActa Universitatis Lodziensis. Folia Oeconomica, 2019
The problem of determining unknown measurements of objects in the model of spring balance weighing designs is presented. These designs are considered under the assumption that experimental errors are uncorrelated and that they have the same variances ...
Małgorzata Graczyk, Bronisław Ceranka
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

D-optimal designs via a cocktail algorithm [PDF]

open access: yesStatistics and Computing, 2010
A number of changes after accounting for the referees' comments including new examples in Section 4 and more detailed explanations ...
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A Robbins-Monro type learning algorithm for an entropy maximizing version of stochastic Optimality Theory

open access: yes, 2005
The object of the present work is the analysis of the convergence behaviour of a learning algorithm for grammars belonging to a special version -- the maximum entropy version -- of stochastic Optimality Theory.
Fischer, Markus
core   +1 more source

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