Results 71 to 80 of about 13,560,800 (313)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Optimal Designs For the Restricted Maximum Likelihood Estimators in a Random Split-Plot Model
Lithuanian Journal of Statistics, 2017 The design effect for the restricted maximum likelihood estimators of variance components in acompletely randomized split-plot model is studied. The model was used to represent the response generated froman experimental scenario where the whole-plot and
Oluwole Nuga, G. N. Amahia, Fatai Salami
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
D-Invexity and optimality conditions [PDF]
, 1991 In this paper, a generalization of convexity, called d-invexity, is introduced. Substituting d-invex for convex, we get some optimality conditions for nondifferentiable multiobjective programming.
Ye, Y.L
core +1 more source
Evaluating Algorithm Efficiency for Optimizing Experimental Designs with Correlated Data
Algorithms, 2018 The search for efficient methods and procedures to optimize experimental designs is a vital process in field trials that is often challenged by computational bottlenecks.
Lazarus K. Mramba, Salvador A. Gezan
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Computational Optimality Theory
, 1995 In Optimality Theory, a linguistic input is assigned a grammatical structural description by selecting, from an infinite set of candidate structural descriptions, the description which best satisfies a ranked set of universal constraints.
core +1 more source
Transcripts enriched in codons that trigger P-site tRNA-mediated mRNA decay possess stable mRNA. [PDF]
FEBS Open BioPTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Carneiro RL, Palhano FL.
europepmc +2 more sources
On the growth problem for D-optimal designs
, 1997 When Gaussian elimination with complete pivoting (GECP) is applied to a real n×n matrix A, we will call g(n, A) the associated growth of the matrix. The problem of determining the largest growth g(n) for various values of n is called the growth problem. It seems quite difficult to establish a. value or close bounds for g(n). For specific values of n (n=
Mitrouli, M., Koukouvinos, C.
openaire +3 more sources