Results 71 to 80 of about 10,339,939 (316)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Approximating quantum channels by completely positive maps with small Kraus rank [PDF]

open access: yesQuantum
We study the problem of approximating a quantum channel by one with as few Kraus operators as possible (in the sense that, for any input state, the output states of the two channels should be close to one another).
Cécilia Lancien, Andreas Winter
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Evaluating Algorithm Efficiency for Optimizing Experimental Designs with Correlated Data

open access: yesAlgorithms, 2018
The search for efficient methods and procedures to optimize experimental designs is a vital process in field trials that is often challenged by computational bottlenecks.
Lazarus K. Mramba, Salvador A. Gezan
doaj   +1 more source

Optimal State Transfer and Entanglement Generation in Power-Law Interacting Systems

open access: yesPhysical Review X, 2021
We present an optimal protocol for encoding an unknown qubit state into a multiqubit Greenberger-Horne-Zeilinger-like state and, consequently, transferring quantum information in large systems exhibiting power-law (1/r^{α}) interactions.
Minh C. Tran   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Computational Optimality Theory

open access: yes, 1995
In Optimality Theory, a linguistic input is assigned a grammatical structural description by selecting, from an infinite set of candidate structural descriptions, the description which best satisfies a ranked set of universal constraints.

core   +1 more source

On the growth problem for D-optimal designs

open access: yes, 1997
When Gaussian elimination with complete pivoting (GECP) is applied to a real n×n matrix A, we will call g(n, A) the associated growth of the matrix. The problem of determining the largest growth g(n) for various values of n is called the growth problem. It seems quite difficult to establish a. value or close bounds for g(n). For specific values of n (n=
Mitrouli, M., Koukouvinos, C.
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

GNSS Monitoring Network Optimization Case Study: Opak Fault Deformation, Yogyakarta

open access: yesJournal of Geospatial Information Science and Engineering, 2018
Opak fault is a fault located in Opak River area, Bantul. The existence of the fault is one of the biggest causes of earthquake in Yogyakarta in 2006. The seismic potential caused by the active fault requires continuous geodynamic monitoring.
Nurrohmat Widjajanti   +2 more
doaj   +1 more source

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