Results 241 to 250 of about 15,108,845 (313)

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Hyperthermia‐induced cytotoxicity and modulation of PD‐L1 and MHC‐I expression in human non‐small cell lung cancer cell lines

Experimental Physiology, EarlyView.
Abstract Hyperthermia has recently been applied to treat human non‐small cell lung cancer (NSCLC). However, the mechanisms underlying cytotoxic sensitivity of NSCLC cells to hyperthermia are not fully understood. In this study, five NSCLC cell lines with different epidermal growth factor receptor (EGFR), Kirsten rat sarcoma and tumor protein p53 ...
Yun‐Chieh Tu, Wei‐Chen Yeh, Yi‐Wei Fang, Ko‐Hsuan Lo, Lei‐Ni Liang, Xu‐Chen Liu, Chia‐Chi Tsai, Chih‐Cheng Cheng, Meng‐Chieh Lin, Hsin‐Hsien Yu, Bor‐Chyuan Su   +10 more
wiley   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Vagus Nerve Stimulation Paired With Tones Alters the Auditory Cortex Proteome in a Rat Model of Rett Syndrome

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Rett syndrome is a neurodevelopmental disorder caused by an X‐linked mutation of the MeCP2 gene. Individuals with Rett syndrome, as well as rodent models of this disorder, demonstrate abnormal cortical responses to sound, which impair auditory discrimination ability.
Isabella K. Myers, Fang Bian, Maria P. Solano, Yara El Zoghby, Diana Tavares‐Ferreira, Tanya Danaphongse, Crystal T. Engineer   +6 more
wiley   +1 more source

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d-ribose and pathogenesis of Alzheimer’s disease

Molecular Biology Reports, 2020
It is estimated that the global prevalence of dementia will rise as high as 24 million and predicted to be double in every 20 years which is attributed to the fact that the ageing population is increasing and so more individuals are at risk of developing neurodegenerative diseases like Alzheimer's.
Mehjbeen, Javed, Md Irshad, Ahmad, Hina, Javed, Sufia, Naseem   +3 more
openaire   +3 more sources

Mass spectrometry of d-ribose molecules

International Journal of Mass Spectrometry, 2019
Abstract The results of mass spectra of d -ribose molecular beam study by electron impact for the 20–70 eV energy range at the evaporation temperature 310–430 K are presented. The experiment was carried out in two stages: first the mass spectra were measured in the range of 0–200 Da at different ionization energies, then relative cross-sections of ...
A.N. Zavilopulo, O.B. Shpenik, A.N. Mylymko, V. Yu. Shpenik   +3 more
openaire   +2 more sources

Synthetic Supramolecular Host for D‐(−)‐Ribose: Ratiometric Fluorescence Response via Multivalent Lectin‐Carbohydrate Interactions

ChemBioChem, 2022
Easily synthesizable, carbazole‐based organic nanoaggregates have been designed for selective detection of D‐(−)‐ribose at physiological pH. The addition of D‐ribose results in a ratiometric change in fluorescence color from green to cyan (LOD: ∼12 μM ...
Rikitha S Fernandes, N. Dey
semanticscholar   +1 more source

Serum oxidized low density lipoprotein serves as a mediator for the inverse relationship between serum D-ribose and cognitive performance in type 2 diabetic patients.

Free Radical Biology & Medicine, 2021
Chronic hyperglycemia, proinflammatory state, and oxidative stress are implicated in the etiology of mild cognitive impairment (MCI) in type 2 diabetes mellitus (T2DM) patients.
Yanhui Lu, Hua Jiang, Huijing Zhang, Ruxue Li, Qi Zhang, D. Luo, Xue Cai, Mingzi Li   +7 more
semanticscholar   +1 more source

Nonenzymatic glycosylation of isolated human immunoglobulin‐G by D‐ribose

Cell Biochemistry and Function, 2022
Glycation is vital in terms of its damaging effect on macromolecules resulting in the formation of end products, which are highly reactive and cross‐linked irreversible structures, known as advanced glycation end products (AGEs).
Saheem Ahmad, Khalid Al-Shaghdali, S. Rehman, M. Y. Khan, Zeeshan Rafi, M. Faisal, A. A. Alatar, Iram Khan Tahir, Saif Khan, Shafeeque Ahmad, Uzma Shahab   +10 more
semanticscholar   +1 more source