A Multi Targeting Conditionally Replicating Adenovirus Displays Enhanced Oncolysis while Maintaining Expression of Immunotherapeutic Agents. [PDF]
PLoS ONE, 2015 Studies have demonstrated that oncolytic adenoviruses based on a 24 base pair deletion in the viral E1A gene (D24) may be promising therapeutics for treating a number of cancer types.
G Clement Dobbins +3 more
doaj +7 more sources
When Classic Signs Deceive: A Widespread Papulosquamous Eruption in Skin of Colour [PDF]
DermatopathologyA 29-year-old gentleman of African descent presented to the emergency department with a three month history of a rash affecting the trunk, upper limbs, and thighs.
Ji Fung Yong +4 more
doaj +2 more sources
Immunostaining of P450c17, Aromatase and Oestrogen Receptor Alpha in Germ and Somatic Cells During Gonadal Development in Greater Rhea. [PDF]
Anat Histol EmbryolABSTRACT The greater rhea (Rhea americana), the largest bird species in South America, has significant economic value due to its meat, eggs, leather, feathers and oil. However, its lack of external sexual dimorphism poses challenges for reproductive management and breeding programmes.
Cristofoli M +7 more
europepmc +2 more sources
Ad6-Based GM-CSF Expressing Vector Displays Oncolytic and Immunostimulatory Effects in an Immunocompetent Syrian Hamster Model of Cholangiocarcinoma [PDF]
VirusesCholangiocarcinoma (CCA), the second most common liver cancer, remains highly resistant to chemotherapy and radiotherapy, leaving patients with unresectable tumors in urgent need of innovative therapeutic approaches.
Daria S. Zabelina +10 more
doaj +2 more sources
Nucleoside-Based Hydrogel Platform Synergizes with Photothermal Effects for Enhanced Biofilm Eradication Against Periodontitis. [PDF]
Adv Sci (Weinh)A synergistic antibiofilm hydrogel platform (ZBAg@FNP) is developed by encapsulating an organic small‐molecule photothermal agent (FNP) within a silver ion‐mediated supramolecular hydrogel (ZBAg), enabling photothermal disruption of biofilm integrity and controlled Ag⁺ ion release upon irradiation.
Wen Y +8 more
europepmc +2 more sources
Personalized management of hypertensive patients: focus on prognostic biomarkers
Российский кардиологический журнал, 2022 Aim. To analyze level of circulating biomarkers of plasma vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α) during 3-month therapy with a fixed-dose combination of ramipril/indapamide (Konsilar-D24, AO Vertex, Russia), as well
S. V. Lyamina +2 more
doaj +1 more source
Small-Bowel Capsule Endoscopy—Optimizing Capsule Endoscopy in Clinical Practice
Diagnostics, 2021 The small bowel is the longest organ within the gastrointestinal tract. The emergence of small bowel capsule endoscopy (SBCE) over the last 20 years has revolutionized the investigation and diagnosis of small bowel pathology.
Fintan O’Hara, Deirdre McNamara
doaj +1 more source
The challenge of primary gastric melanoma: a systematic review
Melanoma Management, 2020 Aim: Primary gastric melanoma is a rare clinical presentation. The purpose of this review was to compare the 1-year survival in patients who underwent surgery with patients who did not receive treatment.
Gregory S Mellotte +5 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2020 Background Ovarian cancers often contain significant numbers of tumor-infiltrating lymphocytes (TILs) that can be readily harnessed for adoptive T-cell therapy (ACT).
Akseli Hemminki +11 more
doaj +1 more source
Renormalization Group Analysis of Tachyon Condensation [PDF]
, 2001 Renormalization group analysis of boundary conformal field theory on bosonic D25-brane is used to study tachyon condensation. Placing the lump on a finite circle and triggering only the first three tachyon modes, the theory flows to nearby IR fixed point
Dasgupta, Satabhisa, Dasgupta, Tathagata
core +2 more sources