Results 41 to 50 of about 1,406 (146)

An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

Advanced Science, Volume 12, Issue 42, November 13, 2025.
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian, Wenzhu Guo, Yanjing Wang, Weiwei Wen, Weixuan Wang, Ling Jiang, Qiuju Liang, Ji'an Liu, Haijun Liu, Yuan Xue, Lixu Pan, Qiaoquan Liu, Ping Yin, Delin Zhang, Jianbing Yan, Chunyi Zhang   +15 more
wiley   +1 more source

The image of Ekaterinoslav as an unrealized potentiality in Russian travelogues of the late 18th — 19th centuries [PDF]

Слово.ру: балтийский акцент
The paper examines the representation of Ekaterinoslav’s urban space based on twenty-two Russian travelogues of the late 18th—19th centuries (texts by Ivan Ya. Akinfiev, Alexander S. Afanasyev, Pavel A. Bibikov, Ivan F. Vernet, Fyodor F. Vigel, Alexander
Sergei S. Zhdanov
doaj   +1 more source

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, Volume 12, Issue 40, October 27, 2025.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source

Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens

Emerging Microbes and Infections, 2018
Human adenoviruses (HAdVs) are uniquely important “model organisms” as they have been used to elucidate fundamental biological processes, are recognized as complex pathogens, and are used as remedies for human health.
Ashrafali M. Ismail, Tiange Cui, Kalpana Dommaraju, Gurdeep Singh, Shoaleh Dehghan, Jason Seto, Susmita Shrivastava, Nadia B. Fedorova, Neha Gupta, Timothy B. Stockwell, Ramana Madupu, Albert Heim, Adriana E. Kajon, Eric G. Romanowski, Regis P. Kowalski, Jambulingam Malathi, Kuzhanthai L. Therese, Hajib Narahari Madhavan, Qiwei Zhang, Leonardo J. Ferreyra, Morris S. Jones, Jaya Rajaiya, David W. Dyer, James Chodosh, Donald Seto   +24 more
doaj   +1 more source

DR and SPIT: Statistical approaches for identifying transient structure in intrinsically disordered proteins via NMR chemical shifts

Protein Science, Volume 34, Issue 9, September 2025.
Abstract Intrinsically disordered proteins (IDPs) play key roles in various biological processes; they are associated with liquid–liquid phase separation and are targets in disorder‐based drug design. Efforts to identify their structural propensities—that can be linked to molecular recognition, malfunction, targeting—still lead to ambiguous results ...
Dániel Kovács, Andrea Bodor
wiley   +1 more source

Spatio-Temporal Redistribution of Traffic Flows during Sequential Blocking of Channels at a Signalized Intersection: A Probabilistic Approach (Case Study of Augustusplatz, Leipzig)

Communications
The spatiotemporal redistribution of traffic flows under alternating blocking of channels at a signalized four-leg intersection is investigated using the case of Augustusplatz in Leipzig, Germany.
Dmitry Ganzheev, Anatoliy Falendysh, Pavol Šťastniak, Olha Kletska, Kristína Kozáková, Kateryna Kravchenko   +5 more
doaj   +1 more source

Inorganic carbon levels regulate growth via SigC signaling cascade in cyanobacteria

New Phytologist, Volume 247, Issue 5, Page 2118-2133, September 2025.
Summary Cyanobacterial growth depends on inorganic carbon (Ci; CO2 and bicarbonate) concentration, but mechanism(s) adjusting photosynthesis and growth according to Ci remain unclear. ΔrpoZ cells lacking the ω subunit of the RNA polymerase (RNAP) show a unique high‐CO2 lethal phenotype in Synechocystis sp. PCC 6803.
Juha Kurkela, Linda Vuorijoki, Serhii Vakal, Otso Turunen, Satu Koskinen, Viktoria Reimann, Mithila Ray, Wolfgang R. Hess, Tiina A. Salminen, Taina Tyystjärvi   +9 more
wiley   +1 more source

Biodegradation, mechanical and biocompatibility evaluation of compact and porous polylactic acid after long‐term dynamic fluid immersion

Journal of Chemical Technology &Biotechnology, Volume 100, Issue 8, Page 1632-1644, August 2025.
Abstract BACKGROUND Polylactic acid (PLA) is the most widely used thermoplastic in applications in the benefit of humans, such as biomedicine and food packaging. However, its behaviour when operating in relevant environments has not been fully investigated.
DV Portan, A Angelopoulou, A Koliadima, LC Kontaxis, G Michanetzis, D Kouzoudis, E Michalopoulos, GC Papanicolaou   +7 more
wiley   +1 more source

THE ROLE OF FISCAL STIMULUS AND MONETARY EASING IN INDONESIAN ECONOMY DURING GLOBAL FINANCIAL CRISIS: FINANCIAL COMPUTABLE GENERAL EQUILIBRIUM APPROACH

Buletin Ekonomi Moneter dan Perbankan, 2010
Global financial crisis started in mid 2008 has reduced global economic growth, and many countries even experienced economic contraction. To deal with economic contraction, various economic policies have been undertaken. Governments have increased fiscal
Iskandar Simorangkir, Justina Adamanti
doaj   +1 more source

Immunotherapy using pullulan‐conjugated Der f 2 allergen in canine atopic dermatitis: An anti‐inflammatory agent‐sparing approach

Veterinary Dermatology, Volume 36, Issue 4, Page 443-452, August 2025.
Background – Allergen immunotherapy is used as aetiological treatment for canine atopic dermatitis (cAD). Objective – To assess the anti‐inflammatory agent‐sparing effect over 1 year of immunotherapy using pullulan‐conjugated recombinant Der f 2 (rDf2‐P). Conclusions and Clinical Relevance – Der f 2‐P immunotherapy can lead to a rapid reduction in anti‐
Masahiko Nagata, Jin Kozakai, Aya Yoshida, Kana Kameyama, Hiromi Oboso, Hisanori Muto, Shoji Ogino, Toshihiro Tsukui   +7 more
wiley   +1 more source