Results 51 to 60 of about 1,852 (182)

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, Volume 12, Issue 40, October 27, 2025.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source

Measurement of relative branching fractions of B decays to ψ(2S) and J/ψ mesons [PDF]

, 2012
The relative rates of B-meson decays into J/ψ and ψ(2S) mesons are measured for the three decay modes in pp collisions recorded with the LHCb detector. The ratios of branching fractions (B) are measured to be B(B +→ψ(2S)K + ) B(B+→J/ψK+) = 0.594±
Harrison, P. F., Dossett, D., Whitehead, M. (Mark), Poluektov, Anton, Kreps, Michal, Reid, Matthew M., Back, J. J., Pilar, T., Williams, M. P., Latham, Thomas, HASH(0x55a67fd5e298), Gershon, T. J., Silva Coutinho, R.   +12 more
core   +1 more source

DR and SPIT: Statistical approaches for identifying transient structure in intrinsically disordered proteins via NMR chemical shifts

Protein Science, Volume 34, Issue 9, September 2025.
Abstract Intrinsically disordered proteins (IDPs) play key roles in various biological processes; they are associated with liquid–liquid phase separation and are targets in disorder‐based drug design. Efforts to identify their structural propensities—that can be linked to molecular recognition, malfunction, targeting—still lead to ambiguous results ...
Dániel Kovács, Andrea Bodor
wiley   +1 more source

Reinventing the Dutch tax-benefit system: exploring the frontier of the equity-efficiency trade-off [PDF]

, 2008
Tax-benefit system, Labour supply, Unemployment, The Netherlands, Applied general equilibrium, D31, D58, H24, J22, J68,
Ruud Mooij
core   +1 more source

Spatio-Temporal Redistribution of Traffic Flows during Sequential Blocking of Channels at a Signalized Intersection: A Probabilistic Approach (Case Study of Augustusplatz, Leipzig)

Communications
The spatiotemporal redistribution of traffic flows under alternating blocking of channels at a signalized four-leg intersection is investigated using the case of Augustusplatz in Leipzig, Germany.
Dmitry Ganzheev, Anatoliy Falendysh, Pavol Šťastniak, Olha Kletska, Kristína Kozáková, Kateryna Kravchenko   +5 more
doaj   +1 more source

THE ROLE OF FISCAL STIMULUS AND MONETARY EASING IN INDONESIAN ECONOMY DURING GLOBAL FINANCIAL CRISIS: FINANCIAL COMPUTABLE GENERAL EQUILIBRIUM APPROACH

Buletin Ekonomi Moneter dan Perbankan, 2010
Global financial crisis started in mid 2008 has reduced global economic growth, and many countries even experienced economic contraction. To deal with economic contraction, various economic policies have been undertaken. Governments have increased fiscal
Iskandar Simorangkir, Justina Adamanti
doaj   +1 more source

Inorganic carbon levels regulate growth via SigC signaling cascade in cyanobacteria

New Phytologist, Volume 247, Issue 5, Page 2118-2133, September 2025.
Summary Cyanobacterial growth depends on inorganic carbon (Ci; CO2 and bicarbonate) concentration, but mechanism(s) adjusting photosynthesis and growth according to Ci remain unclear. ΔrpoZ cells lacking the ω subunit of the RNA polymerase (RNAP) show a unique high‐CO2 lethal phenotype in Synechocystis sp. PCC 6803.
Juha Kurkela, Linda Vuorijoki, Serhii Vakal, Otso Turunen, Satu Koskinen, Viktoria Reimann, Mithila Ray, Wolfgang R. Hess, Tiina A. Salminen, Taina Tyystjärvi   +9 more
wiley   +1 more source

Evaluación de una política de sustitución de energías fósiles para reducir las emisiones de carbono

El Trimestre Económico, 2017
Background: The energy reform from 2008 promotes the generation and use of renewable energy. Methods: The aim of this work is to evaluate the effectiveness of an environmental policy which promotes the replacement of fossil fuels ...
Héctor Bravo Pérez, Juan Carlos Castro Ramírez, Miguel Ángel Gutiérrez Andrade, Elsa Patricia Omaña Pulido   +3 more
doaj  

Biodegradation, mechanical and biocompatibility evaluation of compact and porous polylactic acid after long‐term dynamic fluid immersion

Journal of Chemical Technology &Biotechnology, Volume 100, Issue 8, Page 1632-1644, August 2025.
Abstract BACKGROUND Polylactic acid (PLA) is the most widely used thermoplastic in applications in the benefit of humans, such as biomedicine and food packaging. However, its behaviour when operating in relevant environments has not been fully investigated.
DV Portan, A Angelopoulou, A Koliadima, LC Kontaxis, G Michanetzis, D Kouzoudis, E Michalopoulos, GC Papanicolaou   +7 more
wiley   +1 more source

The macroeconomic impact of pandemic influenza: estimates from models of the United Kingdom, France, Belgium and The Netherlands

, 2010
Macroeconomic modelling, Influenza, Computable general equilibrium, D58,
Marcus Keogh-Brown, John Edmunds, Beutels, Philippe, Richard Smith, Philippe Beutels, Edmunds, John W., Keogh-Brown, Marcus Richard, Smith, Richard D, Edmunds, John W, Smith, Richard D.   +9 more
core   +1 more source