Results 191 to 200 of about 24,783,297 (283)

Rank- and threat-dependent social modulation of innate defensive behaviors. [PDF]

Elife
Li LY, Gao X, Zhang J, Wu WW, Li YT.
europepmc   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Endothelial SLC38A2 controls brain D-serine homeostasis and synapse development. [PDF]

iScience
Tiwari AK, Lahkar A, Sajrawi C, Hussein Y, Majcher A, Bonelli S, Agranovich B, Abramovich I, Stern S, Chaudhry FA, Hornemann T, Radzishevsky I, Wolosker H.   +12 more
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Evaluation of the trūRapid^™ FOUR heartworm antigen test: a reliable point-of-care diagnostic tool for heartworm detection in dogs. [PDF]

Parasit Vectors
Song H, Lamichhane CM, Yang X, Surendran-Nair M, Moore F, Bilbrough G, Evason MD, Vasilatis DM, Willcox JL, Leutenegger CM, Jimenez Castro PD.   +10 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Metaheuristic-driven automatic ARIMA order selection using spider monkey optimization for agricultural production forecasting. [PDF]

MethodsX
Kumar A, H RPC, P FK, Rathod S, Shankar SV, Ray M, B SAS, Patil S, Mazumder C, Mishra SK, Lavanya V, Misra AK, Choudhary VK.   +12 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Timing in smartphone-guided home stroke rehabilitation with functional electrical stimulation: feasibility of distributed supervision and retrospective comparison with a front-loaded model. [PDF]

J Phys Ther Sci
Purohit R, Appelgren-Gonzalez JP, Varas-Diaz G, Hosiasson M, Covarrubias-Escudero F, Bhatt T.   +5 more
europepmc   +1 more source