Results 111 to 120 of about 19,730 (233)

Damping amyloid‐associated conformational fluctuations in a protein by an engineered diselenide bridge

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Polypeptide cross‐β assembly, characteristic of diverse proteotoxic diseases, defines a general thermodynamic ground state and limits the shelf lives of peptide‐ and protein therapeutics. A model is provided by insulin. Although the hormone contains a predominance of α‐helix, its fibrils exhibit cross‐β reorganization.
Yanwu Yang, Balamurugan Dhayalan, Andreas Ehnbom, Orit Weil‐Ktorza, Norman Metanis, Michael A. Weiss   +5 more
wiley   +1 more source

Reply to correspondence on “Metformin and statins reduce hepatocellular carcinoma risk in chronic hepatitis C patients with failed antiviral therapy” [PDF]

Clinical and Molecular Hepatology
Seren M. Gedallovich, Paul Y. Kwo
doaj   +1 more source

Texture and Neonicotinoid Exposure Shape Bacterial Assemblages and Functions in Agricultural Soils: Responses Over Prolonged Exposure

Environmental Microbiology Reports, Volume 18, Issue 4, August 2026.
In a 28‐day soil microcosm experiment, bacterial communities responded differently to imidacloprid across contrasting soil textures, with soil‐dependent changes in community structure, interaction networks and functional pathways, while overall diversity remained largely stable.
Sharmin Akter, Julia Jasonsmith, Nilantha R. Hulugalle, Craig L. Strong, James O. Latimer   +4 more
wiley   +1 more source

Safety and Effectiveness of Glecaprevir/Pibrentasvir in Children and Adolescents With Chronic Hepatitis C: Reports From All‐Case Post‐Marketing Surveillance in Japan

Hepatology Research, Volume 56, Issue 8, Page 1202-1212, August 2026.
ABSTRACT Aim The aim of this all‐case post‐marketing study was to evaluate the real‐world safety and effectiveness in all children and adolescents with chronic hepatitis C with or without compensated cirrhosis treated with glecaprevir/pibrentasvir (G/P) in Japan. Methods This prospective, observational post‐marketing surveillance study was conducted at
Tatsuki Mizuochi, Katsuyoshi Kawana, Mariko Kobayashi, Eri Iwashita, Itaru Iwama, Daiki Abukawa, Hitoshi Tajiri   +6 more
wiley   +1 more source

Modeling Highlights the Challenge of Achieving and Maintaining Hepatitis C Virus Micro-Elimination Among People Who Inject Drugs. [PDF]

Open Forum Infect Dis
Tatara E, Shekhtman L, Collier N, Cotler SJ, Mackesy-Amiti ME, Boodram B, Dahari H, Major M, Ozik J.   +8 more
europepmc   +1 more source

Updated Burden and Long‐Term Projections of Chronic Hepatitis B and C in Japan: A Nationwide Markov Modeling Study

Hepatology Research, Volume 56, Issue 8, Page 1213-1224, August 2026.
ABSTRACT Aim Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remain major causes of liver‐related morbidity and mortality worldwide. Although Japan has implemented nationwide screening and treatment programs for decades, updated nationwide estimates and long‐term projections are limited.
Junko Tanaka, Akemi Kurisu, Ko Ko, Aya Sugiyama, Tomoyuki Akita   +4 more
wiley   +1 more source

Miners' Reward Elasticity and Stability of Competing Proof‐of‐Work Cryptocurrencies

International Economic Review, Volume 67, Issue 3, Page 957-976, August 2026.
ABSTRACT Proof‐of‐Work cryptocurrencies employ miners to sustain the system through algorithmic reward adjustments. We develop a stochastic model of the multicurrency mining and identify conditions for stable transaction speeds. Bitcoin's algorithm requires hash supply elasticity <$<$1 for stability, while ASERT remains stable for any elasticity and ...
Kohei Kawaguchi, Junpei Komiyama, Shunya Noda   +2 more
wiley   +1 more source

Trends in Mortality After the Roll‐Out of Directly Acting Antivirals for Hepatitis C in England Using Linked Surveillance Data

Journal of Viral Hepatitis, Volume 33, Issue 8, August 2026.
ABSTRACT Directly acting antivirals (DAAs) revolutionised hepatitis C virus (HCV) treatment, offering higher cure rates. We aimed to quantify life expectancy (LE) differences between treated and untreated individuals diagnosed with HCV and assess the contributions of age and causes of death to these differences.
David Etoori, Ruth Simmons, Annabel Powell, Monica Desai, Paul Trembling, Caroline Sabin, William Rosenberg   +6 more
wiley   +1 more source

Rootstock genotype influences heat stress-disrupted hormonal regulation and physiological status in pepper ovaries. [PDF]

BMC Plant Biol
Padilla YG, Cruzado-Rodríguez R, Molleja-Pulido G, Calatayud Á, Martínez-Melgarejo PA, Albacete A, López-Galarza S, Gisbert-Mullor R.   +7 more
europepmc   +1 more source

Differing Epidemiology of Chronic Hepatitis C Infection, Treatment, and Outcomes Among Migrants and Australian‐Born Patients

Journal of Viral Hepatitis, Volume 33, Issue 8, August 2026.
ABSTRACT The burden of hepatitis C virus (HCV) infection often falls disproportionately on migrant populations within high‐income countries. Differences in health literacy, language, comorbidities, and HCV genotype may influence HCV natural history. 3537 persons including 652 migrants treated for HCV infection with direct‐acting antiviral (DAA) (2016 ...
Belaynew W. Taye, Patricia C. Valery, Simone I. Strasser, Martin Weltman, Alex J. Thompson, Miriam T. Levy, Barbara Leggett, Amany Zekry, Y. Julian Rong, Marie Sinclair, Jacob George, William Sievert, Gerry MacQuillan, Edmund Tse, Amanda Wade, Wendy Cheng, Stuart K. Roberts, Paul J. Clark   +17 more
wiley   +1 more source