Results 71 to 80 of about 340,341 (299)

Frequency-domain-based complete loss model for 10 kV/1 MW solid-state transformer

open access: yesThe Journal of Engineering, 2019
This study proposes a frequency-domain-based loss model for dual active bridge (DAB) inside modular multi-level cascaded solid-state transformer (SST). Previously, the loss model is mainly derived in the time domain and requires enormous modelling effort.
Tao Liu   +6 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Centroid-Based Clustering with ab-Divergences [PDF]

open access: yes, 2019
Centroid-based clustering is a widely used technique within unsupervised learning algorithms in many research fields. The success of any centroid-based clustering relies on the choice of the similarity measure under use.
Cruces Álvarez, Sergio Antonio   +3 more
core   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Enhancing maize resilience to drought stress: the synergistic impact of deashed biochar and carboxymethyl cellulose amendment

open access: yesBMC Plant Biology
Drought stress poses a significant challenge to maize production, leading to substantial harm to crop growth and yield due to the induction of oxidative stress. Deashed biochar (DAB) in combination with carboxymethyl cellulose (CMC) presents an effective
Subhan Danish   +6 more
doaj   +1 more source

Penggunaan Bentonit sebagai Pengental dalam Proses Pewarnaan Kain Tenun Palembang [PDF]

open access: yes, 2011
This study aims to determine the extent of bentonite can be used as athickener in the process of dyeing cloth dab Tajung Palembang and research has been carried out starting with the manufacture of materials bentonite thickener, making pastadab by ...
Luftinor, L. (Luftinor)
core  

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies [PDF]

open access: yes, 2013
PMCID: PMC3581439This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Trahtenherts   +45 more
core   +3 more sources

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones   +3 more
wiley   +1 more source

Digital Radio Strategies in the United States: A Tale of Two Systems [PDF]

open access: yes, 2010
This essay analyzes how, despite early interest in the Digital Audio Broadcasting standard (DAB) in the United States, an alternative in-band system (HD Radio) was developed as the approved digital radio ...
Huntsberger, Michael, Stavitsky, Alan G.
core   +1 more source

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