Results 191 to 200 of about 1,922 (264)

Chrysin alleviates pressure overload–induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway–mediated oxidative stress response

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In this study, we primarily simulated pathological myocardial remodeling induced by transverse aortic constriction surgery and found significant cardiac hypertrophy and fibrosis, characterized by deteriorated cardiac function. Oxidative stress response is considered as a pivotal pathological process, which contributes to inflammation and apoptosis of ...
Yijia Wang   +12 more
wiley   +1 more source

Automated Dynamic Flow Experimentation for Rapid Kinetic Fitting of Transition Metal Catalysis

open access: yesAngewandte Chemie, EarlyView.
We have developed an automated dynamic flow experimentation platform to automatically fit and identify the most accurate kinetic model from a generated set of candidates. Three transition metal‐catalyzed transformations were performed using this workflow.
Florian L. Wagner   +3 more
wiley   +2 more sources

ALK5 inhibitor impact on bleomycin-induced systemic sclerosis mouse model via multifunctional optical coherence tomography. [PDF]

open access: yesAPL Bioeng
Nikitin PV   +12 more
europepmc   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

open access: yesAnimal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu   +3 more
wiley   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

open access: yesAdvanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia   +10 more
wiley   +1 more source

A Reversible 900 nm Near‐Infrared Photoswitch for Invisibly Writable 2D and 3D Displays

open access: yesAngewandte Chemie International Edition, EarlyView.
The peri‐benzo[a]fluoranthenethioindigo (PBFT) photoswitch enables direct excitation with near‐infrared light up to 900 nm wavelengths. It delivers a high‐performance property profile including high‐contrast color changes between bright green and deep blue.
Elias Ciekalski, Henry Dube
wiley   +1 more source

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