Ventral tegmental area amylin / calcitonin receptor signaling suppresses feeding and weight gain in female rats [PDF]
Neuroscience ResearchThe pancreatic peptide amylin promotes negative energy balance in part through activation of amylin receptors (AmyRs) expressed in the ventral tegmental area (VTA), but studies have been limited to male rodents.
Tyler J. Gustafson +3 more
doaj +2 more sources
A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference. [PDF]
Br J Pharmacol, 2017 Background and PurposeObesity and associated co‐morbidities, such as type 2 diabetes and non‐alcoholic fatty liver disease, are major health challenges. Hence, there is an important need to develop weight loss therapies with the ability to reduce the co‐morbidities.Experimental ApproachThe effect of the dual amylin and calcitonin receptor agonist ...
Gydesen S +7 more
europepmc +5 more sources
Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model [PDF]
Arthritis Research & Therapy, 2019 Background Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease ...
Anna Katri +7 more
doaj +2 more sources
Novel Pharmaceuticals in Appetite Regulation: Exploring emerging gut peptides and their pharmacological prospects. [PDF]
Pharmacol Res PerspectHormonal regulation of the hypothalamic melanocortin system. Abstract Obesity, a global health challenge, necessitates innovative approaches for effective management. Targeting gut peptides in the development of anti‐obesity pharmaceuticals has already demonstrated significant efficacy.
Rubinić I, Kurtov M, Likić R.
europepmc +2 more sources
The Insulin Sensitizer KBP-336 Prevents Diabetes-Induced Cognitive decline in ZDF Rats [PDF]
journal of prevention of Alzheimer's disease, TheAnna Thorsø Larsen
exaly +2 more sources
Improving olefin tolerance and production in E. coli using native and evolved AcrB
Biotechnology and Bioengineering, Volume 112, Issue 5, Page 879-888, May 2015., 2015 The AcrAB‐TolC efflux pump was used to enhance E. coli tolerance towards olefin compounds. Precursors to plastics and polymers, olefins such as 1‐hexene and styrene are good targets for microbial production, but are inhibitory to microbial growth. The AcrAB‐TolC pump was found to be important in the microbial tolerance towards these compounds, and ...
Florence Mingardon +6 more
wiley +1 more source
QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study
Advanced Science, Volume 13, Issue 37, 3 July 2026.The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda +8 more
wiley +1 more source
Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea
Chronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 100-112, June 2026.Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy +3 more
wiley +1 more source
Mediators of Amylin Action in Metabolic Control. [PDF]
J Clin Med, 2022 Boyle CN, Zheng Y, Lutz TA.
europepmc +1 more source
RISING STARS: Targeting G protein-coupled receptors to regulate energy homeostasis. [PDF]
J Mol Endocrinol, 2023 Jamaluddin A, Gorvin CM.
europepmc +1 more source