A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference. [PDF]
Br J Pharmacol, 2017 Background and PurposeObesity and associated co‐morbidities, such as type 2 diabetes and non‐alcoholic fatty liver disease, are major health challenges. Hence, there is an important need to develop weight loss therapies with the ability to reduce the co‐morbidities.Experimental ApproachThe effect of the dual amylin and calcitonin receptor agonist ...
Gydesen S +7 more
europepmc +8 more sources
Ventral tegmental area amylin / calcitonin receptor signaling suppresses feeding and weight gain in female rats. [PDF]
Neurosci ResThe pancreatic peptide amylin promotes negative energy balance in part through activation of amylin receptors (AmyRs) expressed in the ventral tegmental area (VTA), but studies have been limited to male rodents.
Gustafson TJ +3 more
europepmc +2 more sources
Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model. [PDF]
Arthritis Res Ther, 2019 Background Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease ...
Katri A +7 more
europepmc +2 more sources
Novel Pharmaceuticals in Appetite Regulation: Exploring emerging gut peptides and their pharmacological prospects. [PDF]
Pharmacol Res PerspectHormonal regulation of the hypothalamic melanocortin system. Abstract Obesity, a global health challenge, necessitates innovative approaches for effective management. Targeting gut peptides in the development of anti‐obesity pharmaceuticals has already demonstrated significant efficacy.
Rubinić I, Kurtov M, Likić R.
europepmc +2 more sources
The Insulin Sensitizer KBP-336 Prevents Diabetes-Induced Cognitive decline in ZDF Rats. [PDF]
J Prev Alzheimers DisLarsen AT +4 more
europepmc +2 more sources
Mediators of Amylin Action in Metabolic Control. [PDF]
J Clin Med, 2022 Amylin (also called islet amyloid polypeptide (IAPP)) is a pancreatic beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli.
Boyle CN, Zheng Y, Lutz TA.
europepmc +2 more sources
RISING STARS: Targeting G protein-coupled receptors to regulate energy homeostasis. [PDF]
J Mol Endocrinol, 2023 G protein-coupled receptors (GPCRs) have a critical role in energy homeostasis, contributing to food intake, energy expenditure and glycaemic control. Dysregulation of energy expenditure can lead to metabolic syndrome (abdominal obesity, elevated plasma ...
Jamaluddin A, Gorvin CM.
europepmc +3 more sources
El contracte del sepulcre del cardenal Berenguer d'Anglesola [PDF]
, 1998 El sepulcre del cardenal Berenguer d'Anglesola és una de les obres més significatives del gòtic internacional gironí. Fins ara havia estat atribuït a Pere Oller seguint criteris estilístics. El recentment aparegut contracte de la tomba confirma l'autoria
Valero Molina, Joan
core +3 more sources
Improving olefin tolerance and production in E. coli using native and evolved AcrB
Biotechnology and Bioengineering, Volume 112, Issue 5, Page 879-888, May 2015., 2015 The AcrAB‐TolC efflux pump was used to enhance E. coli tolerance towards olefin compounds. Precursors to plastics and polymers, olefins such as 1‐hexene and styrene are good targets for microbial production, but are inhibitory to microbial growth. The AcrAB‐TolC pump was found to be important in the microbial tolerance towards these compounds, and ...
Florence Mingardon +6 more
wiley +1 more source
Familial aggregation of atrial fibrillation: a study in Danish twins [PDF]
, 2009 BACKGROUND: Heritability may play a role in non-familial atrial fibrillation (AF). We hypothesized that a monozygotic (MZ) twin whose co-twin was diagnosed with AF would have an increased risk of the disease compared to a dizygotic (DZ) twin in the same ...
Budtz-Joergensen, Esben +6 more
core +1 more source