DAF-16 is not enriched at the col-19 promoter.
, 2021 ChIP-qPCR experiments were performed on N2 or daf-16(ar620[daf-16::zf1-wrmScarlet-3xFLAG]) dauer larvae. Binding of DAF-16-3xFLAG was first normalized to input, and then to the average of the respective wild-type value (mean +/- SD for two technical ...
Margaret R. Starostik (11708055) +17 more
core +1 more source
DAF-12 regulates a connected network of genes to ensure robust developmental decisions. [PDF]
PLoS Genetics, 2011 The nuclear receptor DAF-12 has roles in normal development, the decision to pursue dauer development in unfavorable conditions, and the modulation of adult aging.
Daniel Hochbaum +7 more
doaj +1 more source
daf-31 encodes the catalytic subunit of N alpha-acetyltransferase that regulates Caenorhabditis elegans development, metabolism and adult lifespan. [PDF]
PLoS Genetics, 2014 The Caenorhabditis elegans dauer larva is a facultative state of diapause. Mutations affecting dauer signal transduction and morphogenesis have been reported. Of these, most that result in constitutive formation of dauer larvae are temperature-sensitive (
Di Chen +5 more
doaj +1 more source
, 2006 Background The provision of stress resistance diverts resources from development and reproduction and must therefore be tightly regulated. In Caenorhabditis elegans, the switch to increased stress resistance to promote survival through periods of ...
Halstead, JR +12 more
core +1 more source
Antibodies against complement-regulatory proteins on platelets in immune thrombocytopenia
Platelets, 2017 In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding.
Ursula Unterberger +3 more
doaj +1 more source
DAF-16 levels increase in ins-1(nj32) mutants and after D- and L-glucose feeding.
, 2022 (A) Representative micrographs of DIC, DAF-16::NeonGreen (DAF-16::NG), and autofluorescence (RFP) under non-heatshock and HS conditions. (B) Quantification of the nuclear/cytosol ratio of normalized fluorescence between HS and non-heatshock (no HS) DAF ...
Ava Handley (12575434) +4 more
core +1 more source
DAF-16/FoxO but not SKN-1/Nrf mediates BMP-insulin regulation of lipid accumulation.
, 2021 A) Overexpression of DAF-16::GFP rescues the low-fat phenotype of dbl-1 mutants while overexpression of SKN-1::GFP does not. B) Loss of daf-16 blocks the high-fat phenotype of ins-4 mutant animals.
Katerina K. Yamamoto (11547614) +8 more
core +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
The thioredoxin TRX-1 modulates the function of the insulin-like neuropeptide DAF-28 during dauer formation in Caenorhabditis elegans. [PDF]
PLoS ONE, 2011 Thioredoxins comprise a conserved family of redox regulators involved in many biological processes, including stress resistance and aging. We report that the C.
Juan Carlos Fierro-González +4 more
doaj +1 more source