Results 51 to 60 of about 29,557 (232)

Dual‐targeted nanomedicine delivering doxorubicin and nitric oxide for tumor immunomodulation and synergistic therapy

open access: yesBMEMat, EarlyView.
The mechanism of HA‐DS@PLGA nanoparticles co‐delivering DOX and SNAP (an NO donor) to suppress tumor growth, remodel the tumor microenvironment, and enhance antitumor immune responses for effective combinatorial cancer therapy. Abstract Cancer therapeutic efficacy is significantly influenced by tumor immunosuppressive environment possibly induced by ...
Xingzhou Peng   +10 more
wiley   +1 more source

The One‐Step Synthesis of Biologically Active Isochromans from Lignin‐Derived Aromatic Monomers in Tunable Deep Eutectic Solvents

open access: yesChemistry – A European Journal, EarlyView.
A straightforward one‐step protocol enables the synthesis of bio‐based and biologically active isochromans through the Oxa‐Pictet cyclization involving diverse aldehydes, including vanillin in combination with lignin‐derivable homovanillyl alcohol, a prominent aromatic platform chemical obtainable via diol‐assisted fractionation of lignocellulose ...
Anjali Kottayi   +6 more
wiley   +1 more source

DAF-16/FOXO promotes taste avoidance learning independently of axonal insulin-like signaling.

open access: yesPLoS Genetics, 2019
The avoidance of starvation is critical for the survival of most organisms, thus animals change behavior based on past nutritional conditions. Insulin signaling is important for nutritional state-dependent behavioral plasticity, yet the underlying ...
Takashi Nagashima   +2 more
doaj   +1 more source

Techno‐Economic and Quasi‐Dynamic Load Flow Analysis of a Hybrid Renewable Microgrid for Coastal Industrial Loads

open access: yesEnergy Science &Engineering, EarlyView.
A hybrid PV–wind grid‐connected microgrid for Mongla Port is optimized using HOMER Pro and validated via DIgSILENT quasi‐dynamic load flow. The system achieves a low cost of energy (0.0341 USD/kWh), 70.9% renewable penetration, improved voltage stability, and significant emission reduction, demonstrating a reliable and cost‐effective solution for ...
Md. Behesty Hasan Sagor   +6 more
wiley   +1 more source

Research on Vehicle-bridge Coupling DAF of Straddle-type MTT Based on Elastic Net Regression

open access: yesChengshi guidao jiaotong yanjiu
ObjectiveThe straddle-type MTTS (monorail tour transit system) is classified as large-scale amusement facilities. Currently, there is relatively limited theoretical research on the vehicle-bridge coupling DAF(dynamic amplification factors) of MTTS, and ...
Changxing WU   +3 more
doaj   +1 more source

Immunomodulatory Effect of Tilapia (Oreochromis niloticus) Scale Gelatin Peptides in RAW264.7 Macrophages and Caenorhabditis elegans

open access: yesFood Safety and Health, EarlyView.
ABSTRACT Currently, small‐molecular‐weight collagen peptides are a research hotspot in functional factor development due to their high bioavailability and diverse bioactivities. In this study, gelatin was extracted from tilapia (Oreochromis niloticus) scales by hot water extraction, followed by pepsin hydrolysis and ultrafiltration to obtain the < 3 ...
Ya‐ru Liu   +5 more
wiley   +1 more source

Die Rolle von Sprachmittlung/Mediation für das (Fremd-)Sprachenlernen und die Weiterentwicklung des (Fremd-)Sprachenunterrichts (an Schulen) im Kontext von Mehrsprachigkeit, Migration und Bildungsauftrag. Eine Stellungnahme

open access: yesZeitschrift für Interkulturellen Fremdsprachenunterricht
Dieser Beitrag postuliert eine stärkere Berücksichtigung von Mediation im (Fremd-)Sprachenunterricht der Zukunft. Denn Mediationskompetenzen sind genuiner Bestandteil der Interaktion in von Migration, Globalisierung und Mehrsprachigkeit geprägten ...
Katharina Schuhmann, Ulrike Arras
doaj   +2 more sources

Combining phenotypic, physiological, and multi‐omics studies to provide new insights on the role of 2,4‐epibrassinolide in regulation of seed shattering in Elymus sibiricus L.

open access: yesGrassland Research, EarlyView.
Abstract Background Seed shattering limits the production of Elymus sibiricus L., and application of exogenous brassinosteroid significantly alleviates plant organ abscission. Methods To explore the potential regulatory network of brassinosteroid on seed shattering, the abscission zone of E. sibiricus cv. Lanyu No.
Huanhuan Lu   +6 more
wiley   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

open access: yesHealth Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying   +6 more
wiley   +1 more source

Site-Directed Mutagenesis Study Revealed Three Important Residues in Hc-DAF-22, a Key Enzyme Regulating Diapause of Haemonchus contortus

open access: yesFrontiers in Microbiology, 2017
Haemonchus contortus (H. contortus) is one of the most important parasites of small ruminants, especially goats and sheep. The complex life cycle of this nematode is a main obstacle for the control and prevention of haemonchosis.
Yan Huang   +8 more
doaj   +1 more source

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