Results 91 to 100 of about 8,364,200 (274)

Peripheral growth hormone induces cell proliferation in the intact adult rat brain

, 2010
Growth hormone (GH) and insulin-like growth factor I (IGF-I) increase cell genesis in several regions of the brains of GH-IGF-I-deficient hypophysectomized rats.
Lind, Johan,, Kuhn, Hans-Georg,, Åberg, N David,, Isgaard, Jörgen,   +3 more
core  

Growth hormone and heart failure: Oxidative stress and energetic metabolism in rats

, 2008
Several evidences point for beneficial effects of growth hormone (GH) in heart failure (HF). Taking into account that HF is related with changes in myocardial oxidative stress and in energy generation from metabolic pathways, it is important to clarify ...
Padovani, Carlos Roberto, Novelli, E. L. B., Okoshi, Katashi [UNESP], Nascimento, A. [UNESP], Castro, A. V. B., Nascimento, A., Ebaid, Geovana Xavier, Ebaid, Geovana Xavier [UNESP], Padovani, Carlos Roberto [UNESP], Cicogna, Antonio Carlos [UNESP], Seiva, F. R. F., Rocha, K. K. H. [UNESP], Seiva, F. R. F. [UNESP], Castro, A. V. B. [UNESP], Okoshi, Katashi, Cicogna, Antonio Carlos, Novelli, E. L. B. [UNESP], Rocha, K. K. H., Cicogna, A. C., Okoshi, K., Padovani, C. R.   +20 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Failure to Demonstrate Anti-Hormonal Antibodies in Rats after Maximal Response to Daily Administration of Growth Hormone.

Experimental Biology and Medicine, 1960
SummarySerum from female rats plateaued while on treatment with a GH-containing extract (after reaching 2.4 times normal adult female size) was ineffective in attenuating GH response of previously uninjected assay rats.
J D, EMERSON, G M, EMERSON
openaire   +2 more sources

The exon3-deleted growth hormone receptor gene polymorphism (d3-GHR) is associated with insulin and spontaneous growth in short SGA children (NESGAS)

, 2017
Objective The effect of a common polymorphism in the Growth Hormone (GH) receptor (d3-GHR) gene on growth, metabolism and body composition was examined in short children born small for gestational age (SGA) on GH treatment.
Thankamony, Ajay, Dunger, David B., Mathilde Gersel Wegmann, Roche, Edna,, Ivarsson, Sten A., Roche, E, Ajay Thankamony, Hoey, Hilary,, Kirk, Jeremy, Ivarsson, Sten-A., Thankamony, A, Rikke Beck Jensen, Jeremy Kirk, Thankamony, Ajay,, Roche, Edna, Juul, Anders,, Söder, Olle, Jensen, Rikke Beck,, Wegmann, Mathilde Gersel, David B. Dunger, Ivarsson, Sten A.,, Ivarsson, Sten-A, Soder, O, Jensen, Rikke Beck, Juul, A, Guftar Shaikh, Söder, Olle,, Edna Roche, Hoey, Hilary, Hoey, H, Kirk, J, Dunger, DB, Kirk, Jeremy,, Dunger, David B, Sten-A. Ivarsson, Anders Juul, Ivarsson, S-A, Wegmann, MG, Hilary Hoey, Juul, Anders, Shaikh, Guftar, Wegmann, Mathilde Gersel,, Dunger, David B.,, Shaikh, Guftar,, Lund University., Shaikh, G, Olle Söder   +46 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The effect of a period of intensive exercise on the isoform test to detect growth hormone doping in sports.

, 2013
OBJECTIVE: The major objective of this study was to investigate the effects of several days of intense exercise on growth hormone (hGH) testing using the World Anti-Doping Agencies hGH isoform differential immunoassays.
Giraud, S., Schumacher, Y.O., Saugy, M., Robinson, N., Bourdon, P.C., Voss, S.C., Alsayrafi, M.   +6 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Osteosarcoma associated with diamond-blackfan anaemia: a case of a child receiving growth hormone therapy [PDF]

, 2004
Purpose: Diamond–Blackfan anaemia (DBA) is a rare pure congenital red cell aplasia, usually presenting in infancy or early childhood. The literature suggests a predisposition to haemopoietic malignancy but in addition solid tumours have been reported ...
Briggs, TW, Pringle, J, Lee, RS, Higgs, D, Haddo, O   +4 more
core  

Growth Hormone Dose-Dependent Pubertal Growth: A Randomized Trial in Short Children with Low Growth Hormone Secretion

, 2014
Background/Aims: Growth hormone (GH) treatment regimens do not account for the pubertal increase in endogenous GH secretion. This study assessed whether increasing the GH dose and/or frequency of administration improves pubertal height gain and adult ...
Albertsson-Wikland, Kerstin, Lundberg, Elena,, Albertsson-Wikland, K, Jonsson, B, Ritzen, Martin, Aman, Jan, Ivarsson, Sten-A., Gustafsson, J, Ivarsson, Sten, Kristrom, Berit, Jonsson, Bjorn, Hagenäs, Lars,, Ivarsson, Sten-A, Ritzen, M, Hagenas, Lars, Ivarsson, Sten,, Kriström, Berit,, Westgren, Ulf,, Lundberg, E, Aronson, A. Stefan,, Aronson, AS, Tuvemo, Torsten,, Aronson, A Stefan, Aronson, A. Stefan, Tuvemo, T, Ivarsson, Sten-A.,, Hagenas, L, Westgren, Ulf, Gustafsson, Jan,, Lundberg, Elena, Jonsson, Björn,, Tuvemo, Torsten, Ivarsson, S-A, Gustafsson, Jan, Kristrom, B, Westphal, Otto, Albertsson-Wikland, Kerstin,, Westphal, Otto,, Lund University., Aman, Jan,, Ivarsson, Sten-A,, Ritzén, Martin,, Aronson, A Stefan,   +42 more
core   +1 more source