Results 81 to 90 of about 8,364,200 (274)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A comparison of different definitions of growth response in short prepubertal children treated with growth hormone

, 2011
How to define poor growth response in the management of short growth hormone (GH)-treated children is controversial.
Tapanainen, P,, Bang, Peter,, P. Bang, Bjerknes, R., Dahlgren, J, Gustafsson, J, Bjerknes, R,, Dunkel, L,, Dunkel, L., V. Åberg, J. Gustafsson, Bang, P., Aberg, V, Bang, P,, Bang, P, Tapanainen, P., Juul, A, Kriström, Berit,, R. Bjerknes, Bjerknes, R, Gustafsson, J,, Dahlgren, J., Dahlgren, J,, Kriström, B, Kriström, B., Gustafsson, Jan,, L. Dunkel, A. Juul, Kriström, B,, Tapanainen, P, J. Dahlgren, Åberg, V., B. Kriström, P. Tapanainen, Juul, A,, Åberg, V,, Juul, A., Dunkel, L, Dahlgren, Jovanna,   +38 more
core   +1 more source

Prevalence of refractoriness when testing growth hormone levels in children

, 2023
Objective: Late night spontaneous growth hormone (GH) pulses may influence the pituitary GH response to provocation tests. We evaluated GH response during arginine-insulin-tolerance test (AITT) after a GH peak during a short spontaneous nocturnal profile
Maria Elfving, Boije, Victoria, Bengt Lindberg, Victoria Boije, Camilla Borghammar, Borghammar, Camilla, Becker, Charlotte, Lindberg, Bengt, Charlotte Becker, Elfving, Maria, Borghammar, Camilla,, Elfving, Maria,, Boije, Victoria,, Lindberg, Bengt,, Lund University., Becker, Charlotte,   +15 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Growth hormone increases dendritic spine density in primary hippocampal cell cultures

, 2020
Objective: Growth hormone (GH) is widely known for its peripheral effects during growth and development. However, numerous reports also suggest that GH exert pro-cognitive, restorative, and protective properties in the brain.
Zelleroth, Sofia,, Nyberg, Fred,, Grönbladh, Alfhild,, Stam, Frida,, Hallberg, Mathias,, Nylander, Erik,   +5 more
core   +1 more source

Growth cartilage expression of growth hormone/insulin-like growth factor I axis in spontaneous and growth hormone induced catch-up growth [PDF]

, 2012
Introduction: Catch-up growth following the cessation of a growth inhibiting cause occurs in humans and animals. Although its underlying regulatory mechanisms are not well understood, current hypothesis confer an increasing importance to local factors ...
Santos Rodríguez, Fernando, Caldas-Afonso, A, Loredo, V, Caldas-Afonso, Alberto, Santos, F, Tiago Henriques-Coelho, Coelho, Tiago Alexandre Henriques, Brito, Iva, Gil-Peña, H, Loredo López, Vanessa, Molinos, I, Gil Peña, Helena, Brito, I, Molinos Norniella, Inés   +13 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source