Results 161 to 170 of about 4,714,251 (292)

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source

Milk yield characteristics of Karaka sheep

, 2003
Milk yield and composition were determined in a total of 85 Karakas ewes (Akkaraman breed). The data were collected from Yuzuncu Yil University, Agriculture Faculty's Practice Farm and a rural farm near the University.
Karaca, O, Altin, T, Akyuz, N, Andic, Seval   +3 more
core  

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Partial milking of cattle in smallholder herds on the Accra plains. 1. some factors affecting daily partial milk yield and milk composition

, 2013
Presents a study undertaken to measure the partial milk yields of cows, the composition of milk and some environmental factors that influence partial milk extracted under smallholder agropastoral management conditions on the Accra plains in Ghana.
Okantah, S.A.
core   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

The effect of breeding area, stage of lactation and herd on milk yield traits of Pag sheep

Mljekarstvo, 2012
The objective of this study was to determine the effect of different breeding areas (south-west and north-east part of the island of Pag) on daily milk, fat and protein yield in Pag sheep. The aim of thisstudy was also to determine the shape of lactation
Zdravko Barać, Boro Mioč, Marija Špehar   +2 more
doaj  

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Advancing Energy Efficiency in Smart Windows via Dual‐Responsive Electro‐Thermochromism

Advanced Science, EarlyView.
A durable and stable quasi‐solid‐state electro‐thermal dual‐responsive photothermal regulation device has been employed in advanced energy‐efficient smart windows. The devised device not only incorporates a thermochromic hydrogel characterized by high ionic conductivity, high optical transmittance, and a low LCST, but also comprises an electrochromic ...
Tongyu Chen, Bing Xu, Guolong Zhou, Wenting Wu, Bingkun Huang, Xiaohui Tang, William W. Yu, Pooi See Lee, Wu Zhang, Zhongyang Wang, Jingwei Chen   +10 more
wiley   +1 more source

NUMBER OF COLLECTIONS OF MILK YIELD ON PREDICTION OF MODELS TO ESTIMATE AVERAGE DAILY MILK YIELD OF NELLORE BEEF COWS

, 2009
Objetivou-se com este experimento avaliar modelos com diferentes números de coletas da produção de leite para estimativa da produção média diária de leite em vacas Nelore até os 217 dias de lactação. As oito avaliações da produção de leite foram realizadas em 29 vacas, através do método direto, aos 14, 42, 70, 98, 126, 154, 182 dias e ao desmame (217 ...
Pacheco, Paulo Santana, Restle, João, Brondani, Ivan Luiz, Silva, José Henrique Souza da, Miotto, Fabrícia Rocha Chaves, Neiva, José Neuman Miranda   +5 more
openaire   +1 more source