Results 61 to 70 of about 874,081 (300)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Mobilités quotidiennes et modes d’habiter dans le périurbain francilien
Netcom, 2015 In a research devoted to ways of periurban living (Aguilera et al, 2014), we have collected material to question 3 aspects : territory - technical networks (ICT, automotive) - daily mobility, based on statements of thirty-one households living in Paris ...
Patricia Sajous +3 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Cybergeo, 2011 In this article, we compare two databases, one providing mobility data for 34 European cities (UITP database), and the other database providing population density grid cells for these cities at 200m scale.
Florent Le Néchet
doaj +1 more source
Autonomous technologies for daily personal mobilities
European Journal of Geography, 2023 This article attempts to point to emerging future trends for personal mobilities, focusing on the current and upcoming uses of autonomous technologies for both physical and virtual mobilities. These uses will be based on electricity and the Internet, which also constitute mobility modes.
openaire +2 more sources
A different glimpse into mobilities: On the interrelations between daily spatial mobility and social mobility [PDF]
The Information Society, 2017 We explore the link between daily spatial mobility and social mobility, taking changes in the contemporary labor market and family as examples.
Fortunati, Leopoldina, Taipale, Sakari
openaire +3 more sources
Management of Urban Mobility to Control Climate Change in Cities [PDF]
, 2013 The need of decarbonization of urban mobility is one of the main priorities for all countries to achieve greenhouse gas (GHG) emissions reduction targets.
Monzón de Cáceres, Andrés +1 more
core +3 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Cybergeo, 2019 This paper analyzes the evolution in transport modal use in daily mobility of workers in the greater Paris area in the last decade. After many decades of continuous growth, car use has decreased while public transport, walking, cycling and motorized two ...
Laurent Proulhac
doaj +1 more source
The determinants of receiving social care in later life in England [PDF]
, 2013 Demographic change and policy changes in social care provision can affect the type of social care support received by older people, whether through informal, formal state or formal paid-for sources.
Evandrou, M. +3 more
core +2 more sources