Results 71 to 80 of about 122,160 (314)

Distance in spatial interpolation of daily rain gauge data

, 2005
Spatial interpolation of rain gauge data is important in forcing of hydrological simulations or evaluation of weather predictions, for example. The spatial density of available data sites is often changing with time.
Ahrens, B., Ahrens, Bodo
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Systematical Evaluation of Three Gridded Daily Precipitation Products Against Rain Gauge Observations Over Central Asia

Frontiers in Earth Science, 2021
Understanding the precipitation variability and extreme precipitation over arid Central Asia (CA) has largely been hampered by the lack of daily precipitation observations. The gridded precipitation datasets over CA are large discrepancies.
Tuoliewubieke Dilinuer, Junqiang Yao, Jing Chen, Yong Zhao, Weiyi Mao, Jiangang Li, Lianmei Yang   +6 more
doaj   +1 more source

Changes to the temporal distribution of daily precipitation

Geophysical Research Letters, 2014
AbstractChanges to the temporal distribution of daily precipitation were investigated using a data set of 12,513 land‐based stations from the Global Historical Climatology Network. The distribution of precipitation was measured using the Gini index (which describes how uniformly precipitation is distributed throughout a year) and the annual number of ...
Kailash Rajah, Tess O'Leary, Alice Turner, Gabriella Petrakis, Michael Leonard, Seth Westra   +5 more
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Validation of The Weather Generator CLIGEN with Season Precipitation Data in Tokat Province

Turkish Journal of Agriculture: Food Science and Technology, 2019
In models that predict hydrologic, ecological and product-yield relationship, the climate interface file is widely used. Today, CLIGEN is the most widely used climate model.
Saniye Demir, İrfan Oğuz
doaj   +1 more source

Climatological Characteristics of Typical Daily Precipitation

Journal of Climate, 2017
AbstractPrecipitation is often quantified by the amount that falls over a given period of time but not the rate at which most of it falls or the rate associated with the most frequent events. Here, three metrics are introduced to distill salient characteristics of typical daily precipitation accumulation based on the full distribution of rainfall: rain
Angeline G. Pendergrass, Clara Deser
openaire   +1 more source