Results 81 to 90 of about 1,773,066 (262)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
NEW DAILY TEMPERATURE RECORDS IN OLTENIA PRONOUNCED THERMAL CONTRASTS AT THE BEGINNING OF THE SUMMER 2013 [PDF]
Aerul şi Apa: Componente ale Mediului, 2014 The heat waves represent one of the consequences of the globally climate’s warming. These are usually associated with thermal discomfort and drought and sometimes are followed by intervals characterized by a high-degree atmospheric instability and/or ...
MĂNESCU CARMEN +3 more
doaj
Daily variability of river concentrations and fluxes: indicators based on the segmentation of the rating curve [PDF]
, 2012 International audienceThe variability of water chemistry on a daily scale is rarely addressed due to the lack of records. Appropriate tools, such as typologies and dimensionless indicators, which permit comparisons between stations and between river ...
Meybeck, Michel, Moatar, Florentina
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Causalities of the Taiwan Stock Market
, 2003 Volatility, fitting with first order Landau expansion, stationarity, and causality of the Taiwan stock market (TAIEX) are investigated based on daily records.
Canessa +8 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Covariance components by a repeatability model in Slovenian dairy sheep using test-day records
Czech Journal of Animal Science, 2009 The estimation of covariance components for daily milk yield, fat and protein content was performed in three Slovenian dairy sheep breeds (Bovec, Improved Bovec, and Istrian Pramenka).
A. Komprej +3 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Spatial modelling for mixed-state observations
, 2008 In several application fields like daily pluviometry data modelling, or motion analysis from image sequences, observations contain two components of different nature.
Hardouin, Cécile, Yao, Jian-Feng
core +3 more sources