Results 161 to 170 of about 5,119,262 (363)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

RA-risk synovium exhibits DNA damage coupled with impaired DNA repair in fibroblasts. [PDF]

RMD Open
O'Byrne AM, de Jong TA, Semmelink JF, Krawczyk PM, Hoebe RA, van de Sande M, van Baarsen L.   +6 more
europepmc   +1 more source

Strength and Fractal Damage Characteristics of Cement-Coal Slag Stabilized Soil under Freeze-thaw Cycles [PDF]

Kun Ren, Min Shi, M.T. Liang
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Damage identification of reinforced concrete structure based on CNN-ICSA-GWELM model. [PDF]

Sci Rep
You W.
europepmc   +1 more source

Damages unlimited [PDF]

BMJ, 1987
openaire   +2 more sources

A Deep Learning framework for building damage assessment using VHR SAR and geospatial data: demonstration on the 2023 Turkiye Earthquake [PDF]

L. Russo, Deodato Tapete, Silvia Liberata Ullo, Paolo Gamba   +3 more
openalex   +1 more source

ROS and the DNA damage response in cancer

Redox Biology, 2018
U. S. Srinivas, B. W. Tan, B. Vellayappan, Anand D. Jeyasekharan   +3 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Numerical study on blasting damage of rock with eccentric charge structure. [PDF]

PLoS One
Liang K, Zhao H, Li Y, Pan W, Ma F, Rong H, Li N.   +6 more
europepmc   +1 more source