Results 101 to 110 of about 1,392,331 (344)

Progressive failure methodologies for predicting residual strength and life of laminated composites [PDF]

Two progressive failure methodologies currently under development by the Mechanics of Materials Branch at NASA Langley Research Center are discussed. The damage tolerance/fail safety methodology developed by O'Brien is an engineering approach to ensuring
Allen, David H., Harris, Charles E., Obrien, T. Kevin   +2 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Impact of Varied Lead Concentrations on Lead Accumulation in the Body, Heart and Gill Damage of Milkfish (Chanos chanos)

Ilmu Kelautan
Milkfish (Chanos chanos) is valued in aquaculture for its affordability and nutritional richness. However, conventional farming techniques frequently result in suboptimal yields due to lead (Pb) contamination.
Reski Wahyuni Sukardi, Muhammad Iqbal Djawad, Hasni Yulianti Azis, Sharifah Raina Manaf   +3 more
doaj   +1 more source

A Modified Model for Nonlinear Fatigue Damage Accumulation of Turbine Disc Considering the Load Interaction Effect

Metals, 2019
Fatigue damage accumulation theory is one of the core contents in structure fatigue strength design and life prediction. Among them, the nonlinear damage model can overcome the shortcomings of the linear damage model, which takes the loading sequence ...
Tudi Huang, Ru-Chang Ding, Yan-Feng Li, Jie Zhou, Hong-Zhong Huang   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Study on Sand-Accumulation Changes of Highway and Formation Mechanism of Sand Damage in Drifting Dunes Areas [PDF]

, 2022
Feng Han, Chengxiang Wang, Zhibo Liu, Liangying Li, Wenhua Yin   +4 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Numerical Analysis of Resource Characteristics of Structural Elements under Thermocycling Loading [PDF]

Journal of Applied and Computational Mechanics
We discuss methodological aspects of assessment of the service life of structures and devices used in new technologies, paying a particular attention to non-stationary thermomechanical loading of “dangerous” zones of the systems under investigation.
Leonid Igumnov, Ivan Volkov, Andrey Volkov, Victor Eremeyev   +3 more
doaj   +1 more source