Results 111 to 120 of about 1,392,331 (344)

Capital Accumulation And Present-biased Preference [PDF]

open access: yes
This paper reexamines the capital accumulation within a neo-classical growth model under the assumption of hyperbolic discounting as well as endogenous preference, finding that 1) two kinds of Naifs¡¯ behavior coincides under log utility; 2) increasing ...
Heng-fu Zou, Wang Peng
core  

Effects of Light Orientation and Mechanical Damage to Leaves on Isoflavone Accumulation in Soybean Seeds [PDF]

open access: gold, 2021
Giuseppe Barion   +4 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Preparing for catastrophic climate change [PDF]

open access: yes
We study optimal adaptation to climate change when the harmful consequences of global warming are associated with stochastic occurrence of abrupt changes.
Tsur, Yacov, Withagen, Cees
core   +1 more source

Damage analysis of pressure pipes under high temperature and variable pressure conditions [PDF]

open access: yes, 2006
The problem of non-linear stress analysis of creeping reinforced pipes under constant pressure has been treated in a recent work [1]. In the present work, a damage accumulation analysis of the above problem is attempted taking into account the non ...
Arsenos, P.   +7 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications [PDF]

open access: hybrid, 2020
Shalini Singh   +21 more
openalex   +1 more source

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