LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Damage-Accumulation-Induced Crack Propagation and Fatigue Life Analysis of a Porous LY12 Aluminum Alloy Plate. [PDF]
Materials (Basel), 2023 Lv C, Wang K, Zhao X, Wang F.
europepmc +1 more source
DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization [PDF]
, 2017 Alpaslan Tasdogan +13 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Type-I interferon pathway and DNA damage accumulation in peripheral blood of patients with psoriatic arthritis. [PDF]
Front Immunol, 2023 Fragoulis GE +9 more
europepmc +1 more source
A continuous damage model based on stepwise-stress creep rupture tests [PDF]
A creep damage accumulation model is presented that makes use of the Kachanov damage rate concept with a provision accounting for damage that results from a variable stress history.
Robinson, D. N.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Toughness of Network Materials: Structural Parameters Controlling Damage Accumulation. [PDF]
J Mech Phys Solids, 2023 Picu RC, Jin S.
europepmc +1 more source
Comparison of two models of numerical simulation of low cycle fatigue of a plastic material with small grid inclusions [PDF]
, 2013 Theory of Cells and a numerical FE method based on strain cyclic plasticity, damage model and technology of died elements were used for a prediction of the fatigue life of a metal matrix composite material.
Azmetov, Khakim +2 more
core
Quantifying damage accumulation during the hot deformation of free-cutting steels using ultra-fast synchrotron tomography [PDF]
, 2012 Chedtha Puncreobutr +6 more
openalex +1 more source