The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
CRISPR/Cas9 Gene Editing System Can Alter Gene Expression and Induce DNA Damage Accumulation. [PDF]
Genes (Basel), 2023 Yang L +6 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Chronological Age and DNA Damage Accumulation in Blood Mononuclear Cells: A Linear Association in Healthy Humans after 50 Years of Age. [PDF]
Int J Mol Sci, 2023 Vlachogiannis NI +16 more
europepmc +1 more source
Predicting the Remaining Service Life of Civil Airport Runway considering Reliability and Damage Accumulation [PDF]
, 2022 Wei Baoli, Chengchao Guo
openalex +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
The study of a defect evolution in iron under fatigue loading in gigacyclic fatigue regime
Fracture and Structural Integrity, 2015 The work is devoted to the study of the damage accumulation in iron under gigacyclic fatigue (VHCF) regime. The study of the mechanical properties of the samples with different state of life time existing was carried out on the base of the acoustic ...
O. Plekhov, O. Naimark
doaj
Мікромеханіка пошкоджуваності конструкційних матеріалів [PDF]
, 2010 In this article the damage accumulation kinetics of structural materials by the change of volume element, elastic modulus E and linear deformations under axial elastoplastic deformation, elastic modulus G and elastoplastic shear deformations are ...
Грабовський, А. П. +1 more
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
DNA damage accumulation and repair defects in FLT3-ITD acute myeloid leukemia: Implications for clonal evolution and disease progression. [PDF]
Hematol Oncol, 2023 Lagunas-Rangel FA.
europepmc +1 more source