Results 121 to 130 of about 2,407,544 (313)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Flood damage, vulnerability and risk perception - challenges for flood damage research [PDF]
The current state-of-the-art in flood damage analysis mainly focuses on the economic evaluation of tangible flood effects. It is contended in this discussion paper that important economic, social and ecological aspects of flood-related vulnerabilities ...
Messner, Frank, Meyer, Volker
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Two-step Bayesian Structure Health Monitoring Approach for IASC-ASCE Phase II Simulated and Experimental Benchmark Studies [PDF]
, 2003 This report uses a two-step probabilistic structural health monitoring approach to analyze the Phase II simulated and experimental benchmark studies sponsored by the IASC-ASCE Task Group on Structural Health Monitoring.
Beck, James L., Ching, Jianye
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
STS-26 solid rocket booster post flight structural assessment [PDF]
A post flight assessment of the Space Shuttle's Solid Rocket Boosters was conducted at the John F. Kennedy Space Center in Florida after the launch of STS-26.
Finnegan, Charles J., Herda, David A.
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Water and erosion damage to coastal structures: South Carolina Coast, Hurricane Hugo, 1989 [PDF]
, 1990 Hurricane Hugo hit U.S. Mainland on September 21, 1989 just north of Charleston, South Carolina. It was billed as the most costly hurricane on record.
Wang, Hsiang
core
Earthquake Hazard Safety Assessment of Existing Buildings Using Optimized Multi-Layer Perceptron Neural Network [PDF]
, 2020 The latest earthquakes have proven that several existing buildings, particularly in developing countries, are not secured from damages of earthquake.
Harirchian, Ehsan +2 more
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source