Results 51 to 60 of about 288,682 (268)

Laminated Steel Fiber-Reinforced Concrete Hingeless Arch: Research on Damage Evolution Laws

Applied Sciences
In the context of reinforced concrete (RC) arch bridges, while the incorporation of full sections of steel fibers can enhance the bridge’s toughness, cracking resilience, and bearing capacity, achieving an optimal balance between structural performance ...
Zhongchu Tian, Ye Dai, Tao Peng, Zujun Zhang, Yue Cai, Binlin Xu   +5 more
doaj   +1 more source

Damage evolution in marble under uniaxial compression monitored by Pressure Stimulated Currents and Acoustic Emissions

Fracture and Structural Integrity, 2019
The spatiotemporal evolution of damage in marble speci¬mens under uniaxial compression is monitored using Pressure Stimulated Currents (PSCs) and Acoustic Emissions (AEs). The novelty of the study is the use of an integrated grid of sensors (instead of a
Ilias Stavrakas, Stavros K. Kourkoulis, Dimos Triantis   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

EVOLUTIONAL BUILDING DAMAGE PREDICTION

Journal of Structural and Construction Engineering (Transactions of AIJ), 2009
We hypothesized that the scale of the predicted Nankai Earthquake will increase gradually year by year as the time passes from the last occurrence in December 1946, and then we estimated strong motions chronologically from 2009 to 2060 for western Japan based on the up-to-date strong motion prediction method, i.e., the so-called statistical Green's ...
Naranmandora, KAWASE, Hiroshi
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Local Monte Carlo Method for Fatigue Analysis of Coarse-Grained Metals with a Nanograined Surface Layer

Metals, 2018
The fatigue resistance of coarse-grained (CG) metals can be greatly improved by introducing a nanograined surface layer. In this study, the Weibull distribution is used to characterize the spatially-random fracture properties of specimens under axial ...
Xiang Guo, Qiuqiu Sun, Tao Yang, George J. Weng, Cunbo Zhang, Xiqiao Feng   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Identification of the continuum damage parameter: An experimental challenge in modeling damage evolution [PDF]

Acta Materialia, 2012
To accurately predict ductile failures of new advanced metals, continuum damage models (CDM's) require experimental determination of material-specific damage parameter(s). While various experimental techniques are being used to determine these damage parameter(s), possible systematic errors due to methodological difference in damage definition have yet
Tasan, C., Hoefnagels, J., Geers, M.
openaire   +3 more sources