Results 61 to 70 of about 288,682 (268)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Modified Non-Local Damage Model: Resolving Spurious Damage Evolution

Engineering Fracture Mechanics
Accurate prediction of damage and fracture evolution is critical for the safety design and preventive maintenance of engineering structures, however existing computational methods face significant limitations. On one hand, discrete damage and phase-field models are often computationally prohibitive for real world applications and they are less ...
Roshan Philip Saji, Panos Pantidis, Mostafa E. Mobasher   +2 more
openaire   +2 more sources

Seismic Performance Testing and Damage Analysis of Reinforced T-Stub Connections

Buildings
To improve the seismic performance of semi-rigid steel frame beam–column joints connected by T-stubs, reinforced T-stubs formed via wedge-shaped and thickening modifications are proposed.
Yifei Chen, Xin Bu, Bing Shen, Xufeng Yin, Xinwu Wang, Qiang Huang, Zhiwei Zhang   +6 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

In Situ Synchrotron Radiation Computed Tomography Study on Fatigue Damage Evolution of Additively Manufactured Ti-6Al-4V Alloy

Crystals
Additive manufacturing (AM) of Ti-6Al-4V alloy is widely used in aerospace and medical fields due to its excellent strength and corrosion resistance. However, the microstructural heterogeneity induced by the AM process often results in fatigue properties
Hui Wang, Guangcheng Fan, Yu Xiao
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

3D orthogonal woven carbon/carbon composites: micromechanical modeling and damage analysis

Materials Research Express
This study develops a progressive damage model for three-dimensional orthogonal woven car-bon/carbon composites using a micromechanical approach. A Representative Volume Element (RVE) model with periodic boundary conditions is constructed using the ...
Qin Gong, Junhong Chen, Xicheng Huang
doaj   +1 more source

Enhancing Infrastructure Resilience Through Technology: A Study on Fracture and Damage Evolution in Beishan Granite Under Cyclic Loading

Applied Sciences
The fracture behavior of Beishan granite is a critical scientific basis for evaluating and ensuring the long-term safety of geological repositories for high-level radioactive waste under extreme thermal–mechanical conditions.
Gen Li, Chuanle Wang, Yuan Ma, Shihua Dong, Zizheng Sun   +4 more
doaj   +1 more source

Experimental Investigation on Time-Frequency Characteristics of Microseismic Signals in the Damage Evolution Process of Coal and Rock

Energies, 2020
The deformation and failure of coal and rock materials is the primary cause of many engineering disasters. How to accurately and effectively monitor and forecast the damage evolution process of coal and rock mass, and form a set of prediction methods and
Wei Yang, Chengwu Li, Rui Xu, Xunchang Li   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source