Results 71 to 80 of about 4,272,554 (282)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Structural Response of Stiffened Panels Under Repeated Impacts from Rigid and Ice Hammers: An Experimental and Numerical Study

Journal of Marine Science and Engineering
Repeated-impact tests were carried out on a typical stiffened panel using both a wedge-shaped ice indenter and, for comparison, a rigid steel indenter under identical conditions. The tests were performed on a drop-weight impact system under a mass-loaded
Nan Zhao, Yuwen Xu, Fei Li, Tongqiang Yu, Kun Liu   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Mechanical Behaviour and Flow Characteristics of Reservoir Sandstone Under Deep Triaxial Stress Conditions

Applied Sciences
The development of deep oil and gas reservoirs has become a key focus in the exploration and exploitation of hydrocarbon resources. To elucidate the mechanisms governing the flow evolution of reservoir sandstone under deep, high-triaxial stress ...
Shujuan Zhang, Jiyuan Lu, Xueyan Jiang, Xianbao Zheng, Zhiguo Wang, Youchun Wang, Guolong Wang, Qingjin Tang, Tianyu Chen, Xiaoyu Zhang   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Damage evolution mechanism of coal-bearing sandstone under low-temperature thermal cycling in closed-mine geothermal utilization

Meitan xuebao
Mechanical response, damage evolution, and surrounding-rock stability of coal-bearing sandstone under long-term low-temperature thermal cycling are investigated for closed-mine geothermal utilization.
Hai PU, Kangsheng XUE, Yu WU, Zheng MA, Gaobo QU, Dejun LIU   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Study on the Dynamic Mechanical Properties of Deep-Seated Rocks Under Coupled Confining Pressure and Loading Rate

Applied Sciences
Deep rock engineering faces the combined challenges of high in situ stress and dynamic disturbances. However, traditional constitutive models treat confining pressure and rate effects independently, leading to significant prediction errors under high ...
Xuhui Li, Yunhou Sun, Jun Shen, Zailin Yang, Yong Mei, Chenliang Li, Shengyi Cong   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source