Results 121 to 130 of about 740,837 (265)

Thermoelastic stress and damage analysis using transient loading

, 2010
Thermoelastic stress analysis (TSA) is often regarded as a laboratory based technique due to its requirement for a cyclic load. A modified methodology is proposed in which only a single transient load is used for the TSA measurement.
Quinn, S., Fruehmann, R.K, Dulieu-Barton, J.M.   +2 more
core   +1 more source

Identification of Cable-Stayed Bridge Damage Based on Anchor Point Vibrations Caused by Moving Vehicle Loads and Through Machine Learning

Zhongwai Gonglu
The vibration response data on the bridge deck under the load of moving vehicles contains a wealth of information about the geometric parameters of the bridge, enabling effective identification of structural damage.
ZENG Youyi, DU Jiarui, ZHANG Jiabin, WANG Jinhao, FAN Jirong   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

DNA damage responses in the context of the cell division cycle

, 2010
During my PhD, I have investigated aspects of the DNA damage response (DDR) in the context of three different cellular scenarios: DNA damage signalling in response to double-strand breaks during mitosis, coordination of DNA replication with DNA damage ...

core   +1 more source

Influence Line Analysis and Damage Detection of Railway Bridge Deflection with Non-ideal Boundaries

工程科学与技术, 2020
It is difficult to achieve the influence line analysis accurately and damage detection exactly of assembled railway bridge girder because the boundary conditions are somewhere between the rigid and articulation connections.
Lixian WANG, Yu ZHOU, Shengkui DI, Changsheng XIANG   +3 more
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Identification of fully coupled anisotropic plasticity and damage constitutive equations using a hybrid experimental–numerical methodology with various triaxialities

, 2014
A hybrid experimental–numerical methodology is presented for the parameter identification of a mixed nonlinear hardening anisotropic plasticity model fully coupled with isotropic ductile damage accounting for microcracks closure effects.
Badreddine, Houssem, Soyarslan, Celal, Yue, Zhenming, Saanouni, K., Tekkaya, A. Erman   +4 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source