Results 131 to 140 of about 4,651,346 (275)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Research on structural damage identification based on temporal power flow graph network. [PDF]

Sci Rep
Wu X, Lan C, Zhang C, Zhang X, Zhang R, Zhu L.   +5 more
europepmc   +1 more source

Structural Damage Identification Using the Optimal Achievable Displacement Variation. [PDF]

Materials (Basel), 2022
Peng X, Tian C, Yang Q.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Damage identification of reinforced concrete structure based on CNN-ICSA-GWELM model. [PDF]

Sci Rep
You W.
europepmc   +1 more source

Extended Kalman filter algorithm for non-roughness and moving damage identification. [PDF]

Sci Rep, 2022
Ding HL, Zhang C, Gao YW, Huang JP.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Dynamic Response-Based Safety Monitoring and Damage Identification of Concrete Arch Dams via PSO-LSTM. [PDF]

Sensors (Basel)
Qiu J, He W, Long C, Zhang Y, Liu X, Xu P, Sun L, Zhang C, Cheng L, Lu W.   +9 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Stiffness Separation Method for Damage Identification in Continuous Rigid Frame Bridges. [PDF]

Sensors (Basel)
Xiao F, Xu L, Yan Y, Xiang Y.
europepmc   +1 more source