Results 111 to 120 of about 740,837 (265)
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Vibration-based damage detection in plates by using time series analysis
, 2008 This paper deals with the problem for vibration health monitoring (VHM) in structures with nonlinear dynamic behaviour. It aims to introduce two viable VHM methods that use large amplitude vibrations and are based on nonlinear time series analysis.
Trendafilova, I., Manoach, Emil
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
, 2014 Pattern recognition is a promising approach for the identification of structural damage using measured dynamic data. Much of the research on pattern recognition has employed artificial neural networks (ANNs) and genetic algorithms as systematic ways of ...
Chan, Tommy H.T. +2 more
core +1 more source
Identification of Pipe Damage by Line-Structured Light and Regional Resonance Pairs
SensorsBaseline-free methods in structural health monitoring (SHM) are crucial as they allow for real-time damage detection and assessment, eliminating the dependency on initial condition data.
Mingyuan Wang +4 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Identification of damage in composite materials using thermoelastic stress analysis
, 2007 A quantitative damage assessment methodology for composite materials has beenachieved using Thermoelastic Stress Analysis (TSA). The TSA technique provides fullfielddata which is collected in a non-contacting and real time manner.
Emery, Trystan Ross
core
Damage and permeability of composite laminates [PDF]
, 2015 This study focuses on the link between damage development and permeability evolution of composite laminates. By making use of an original device, measurement of the permeability of composite pipes under pressure and quantification of leak paths were ...
BOIS, Christophe +4 more
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