Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Damage Identification of Fiber-Reinforced Composite Thin Plate by Curvature Modal Shape Scanning Method. [PDF]
Materials (Basel)Chang Y +7 more
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Advanced lightweight deep learning vision framework for efficient pavement damage identification. [PDF]
Sci RepDong S +5 more
europepmc +1 more source
Structural Response Prediction for Damage Identification Using Wavelet Spectra in Convolutional Neural Network. [PDF]
Sensors (Basel), 2021 Moscoso Alcantara EA, Bong MD, Saito T.
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Bridge Damage Identification Using Time-Varying Filtering-Based Empirical Mode Decomposition and Pre-Trained Convolutional Neural Networks. [PDF]
Sensors (Basel)Zeng S, Cui J, Luo D, Lu N.
europepmc +1 more source
Damage Identification Method for Medium- and Small-Span Bridges Based on Macro-Strain Data under Vehicle-Bridge Coupling. [PDF]
Materials (Basel), 2022 Zhang H +5 more
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Low-Rank Representation and Data Compression of Full-Field Displacement Maps for Structural Modal Analysis and Damage Identification. [PDF]
Sensors (Basel)Li Y, Huang Y, Li Z, Yin Z, Cao S.
europepmc +1 more source