Results 51 to 60 of about 740,837 (265)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Damage Tolerant Active Contro l: Concept and State of the Art [PDF]

, 2012
Damage tolerant active control is a new research area relating to fault tolerant control design applied to mechanical structures. It encompasses several techniques already used to design controllers and to detect and to diagnose faults, as well to ...
NOBREGA, Euripedes, MECHBAL, Nazih
core  

Damage and repair classification in reinforced concrete beams using frequency domain data

, 2015
This research aims at developing a new vibration-based damage classification technique that can efficiently be applied to a real-time large data. Statistical pattern recognition paradigm is relevant to perform a reliable site-location damage diagnosis ...
Mohammad, FA, Al-Ghalib, AA
core   +1 more source

Assessment of vibration-based damage identification techniques using localized excitation source [PDF]

, 2013
The Bridge Engineering Laboratory in Kitami Institute of Technology, Japan has introduced a number of different damage identification techniques to detect structural damage and identify its location utilizing piezoelectric actuators as a localized ...
Mikami, Shuichi, Oshima, Toshiyuki, Beskhyroun, Sherif, Miyamori, Yasunori   +3 more
core   +1 more source

Multi-Span Box Girder Bridge Sensitivity Analysis in Response to Damage Scenarios

Buildings
Due to their distinct features, including structural simplicity and exceptional load-carrying capacity, steel box girder bridges play a critical role in transportation networks.
Marame Brinissat, Richard Paul Ray, Rajmund Kuti   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Damage localization map using electromechanical impedance spectrums and inverse distance weighting interpolation: Experimental validation on thin composite structures [PDF]

, 2013
Piezoelectric sensors are widely used for structure health monitoring technique. In particular, electromechanical impedance techniques give simple and low-cost solutions for detecting damage in composite structures.
Pommier-Budinger, Valérie, Morlier, Joseph, Selva, Pierre, Lachaud, Frédéric, Cherrier, Olivier   +4 more
core   +1 more source

Research and Evaluation of a New Structural Damage Identification Method Based on a Refined Genetic Algorithm

Applied Sciences
In order to solve the problem of structural damage location and degree identification, the weighted mean of vectors algorithm (INFO), a high-performance optimization algorithm, was first introduced to identify structural damage.
Yuantian Qin, Zhehang Yin, Jiahao Ma
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source