Results 81 to 90 of about 1,741,299 (263)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Evaluation of Damage Indices for Rectangular Concrete-filled Steel Tube Structures

Measurement Science Review, 2019
The paper aims to select a simple and effective damage index for estimating the extent of damage of rectangular concrete-filled steel tube (RCFT) structures subjected to ground motions. Two experimental databases of cyclic tests conducted on RCFT columns
Guan Minsheng, Lin Siying, Du Hongbiao, Cui Jie, Yan Taizhou   +4 more
doaj   +1 more source

Does stroke location predict walk speed response to gait rehabilitation? [PDF]

, 2016
Objectives Recovery of independent ambulation after stroke is a major goal. However, which rehabilitation regimen best benefits each individual is unknown and decisions are currently made on a subjective basis.
Baron, Jean-Claude, Chandler, Elizabeth, Geva, Sharon, Jones, P. Simon, Kerr, Andrew, Marrapu, Siva, Pomeroy, Valerie, Rowe, Philip, Schlaug, Gottfried, Wang, Jasmine   +9 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Phase field approximation of cohesive fracture models [PDF]

, 2014
We obtain a cohesive fracture model as a $\Gamma$-limit of scalar damage models in which the elastic coefficient is computed from the damage variable $v$ through a function $f_k$ of the form $f_k(v)=min\{1,\varepsilon_k^{1/2} f(v)\}$, with $f$ diverging ...
Conti, Sergio, Focardi, Matteo, Iurlano, Flaviana   +2 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Ice storm effects on the canopy structure of a northern hardwood forest after 8 years [PDF]

, 2009
Ice storms can cause severe damage to forest canopies, resulting in differential mortality among tree species and size classes and leading to long-lasting changes in the vertical structure and composition of the forest.
Hamburg, Steven P., Vadeboncoeur, Matthew A., Weeks, Brian C.   +2 more
core   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Direct damage controlled seismic design of plane steel degrading frames [PDF]

, 2014
A new method for seismic design of plane steel moment resisting framed structures is developed. This method is able to control damage at all levels of performance in a direct manner.
A Aschheim, A Erberik, A Ghobarah, A Ghobarah, AA Vasilopoulos, AK Chopra, AK Tiwari, D Loulelis, D Vamvatsikos, D. E. Beskos, DG Lignos, E Cosenza, G Ballio, G. D. Hatzigeorgiou, G. S. Kamaris, GD Hatzigeorgiou, GD Hatzigeorgiou, GD Hatzigeorgiou, GH Powell, GS Kamaris, GS Kamaris, H Sucuoğlu, J Jin, J Song, K Kawashima, LF Ibarra, LF Ibarra, M Abbas, M Abbas, M Raghunandan, M Safar, MJN Priestley, MV Sivaselvan, MV Sivaselvan, N Lam, O Lavan, P Panyakapo, PK Malhotra, S Krishnan, S Leelataviwat, SK Kunnath, T Takeda, TJ Sullivan, TL Karavasilis, TL Karavasilis, Y Lu, YJ Park, YK Wen   +47 more
core   +1 more source