Results 141 to 150 of about 79,411 (313)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A Combined High and Low Cycle Fatigue Life Prediction Model for Wind Turbine Blades

Applied Sciences
A novel method is proposed for a combined high and low cycle fatigue (CCF) life prediction model based on Miner’s rule, incorporating load interactions and coupled damage effects to evaluate the fatigue life of wind turbine blades under CCF loading.
Miaomiao Li, Jianxiong Gao, Jianxing Zhou   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Closed Trans-Scale Statistical Microdamage Mechanics [PDF]

, 2002
Damage and failure due to distributed microcracks or microvoids are on the challenging frontiers of solid mechanics. This appeals strongly to tools not yet fully developed in continuum damage mechanics, in particular to irreversible statistical ...
李晖凌, 白以龙, 柯孚久, 夏蒙棼, Bai, YL (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100080, Peoples R China.   +4 more
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Three-dimensional crack propagation simulation based on a nonlocal algorithm of P91 steel under fatigue and creep–fatigue loading

Mechanical Engineering Journal
This study conducted a three-dimensional crack propagation simulation based on a nonlocal algorithm of P91 steel under fatigue and creep–fatigue loading. A damage-coupled inelastic constitutive model incorporating fatigue and creep damage parameters into
Akihiro MOTOKI, Masayuki ARAI
doaj   +1 more source

Boundary-domain integro-differential equation of elastic damage mechanics model of stationary drilling [PDF]

, 2005
Copyright @ 2005 EC ...
Mikhailov, SE
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Intelligent Models of Wear-Fatigue Damage and Fracture Mechanics

Механика машин, механизмов и материалов
Artificial intelligence technologies are considered in comparison with mathematical modeling using the examples of a number of critical purpose technical systems studied in tribo-fatigue.
Sergei S. Sherbakov
doaj   +1 more source