Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
On the use of constrained reactive mixtures of solids to model finite deformation isothermal elastoplasticity and elastoplastic damage mechanics. [PDF]
J Mech Phys Solids, 2021 Zimmerman BK +4 more
europepmc +1 more source
Mechanical Chondrocyte Damage Thresholds
ASME 2012 Summer Bioengineering Conference, Parts A and B, 2012 Chondrocyte content in articular cartilage is very low. Only 2% to 5% of the tissue volume consists of chondrocytes [1]. Yet, these cells are responsible for maintenance of the tissue. Hence, the loss of chondrocytes that is often occurring at an early stage of cartilage degeneration is detrimental to articular cartilage.
Turnhout, van, M.C. +3 more
openaire +3 more sources
Identification of damage in composite materials using thermoelastic stress analysis [PDF]
, 2007 A quantitative damage assessment methodology for composite materials has beenachieved using Thermoelastic Stress Analysis (TSA). The TSA technique provides fullfielddata which is collected in a non-contacting and real time manner.
Emery, Trystan Ross
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
A Generalized Interpolation Material Point Method for Shallow Ice Shelves. 2: Anisotropic Nonlocal Damage Mechanics and Rift Propagation. [PDF]
J Adv Model Earth Syst, 2021 Huth A, Duddu R, Smith B.
europepmc +1 more source
Practical guidance on the application of R-K integration method in finite element analysis of creep damage problem [PDF]
A practical user guidance of Runge-Kutta (R-K) integration method with the context of non-linear time dependent finite element analysis (FEA) was proposed in this paper.
Tan, Feng +3 more
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Modelagem da evolução do dano ortotrópico acoplado à elastoplasticidade em metais [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópolis, 2010Neste trabalho, estuda-se um modelo de dano dúctil tridimensional baseado nos princípios da mecânica
Freitas, Andresa
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The relative significance of internal damage mechanisms on the overall creep damage and ultimate failure of P91 steel [PDF]
This paper reports research on the study of the relative significance of various internal creep damage mechanisms on the overall creep damage and lifetime of P91 steel.
Yang, Xin, Xu, Qiang, Lu, Zhongyu
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