Results 121 to 130 of about 436,032 (358)
Recent Investigations of the Mechanics of Cavitation and Cavitation Damage [PDF]
, 1955 This paper describes water-tunnel investigations into the mechanics of "fixed"-type cavitation and into the probable mechanism through which this type causes material damage.
Knapp, Robert T.
core
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
On the use of constrained reactive mixtures of solids to model finite deformation isothermal elastoplasticity and elastoplastic damage mechanics. [PDF]
J Mech Phys Solids, 2021 Zimmerman BK +4 more
europepmc +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
A Generalized Interpolation Material Point Method for Shallow Ice Shelves. 2: Anisotropic Nonlocal Damage Mechanics and Rift Propagation. [PDF]
J Adv Model Earth Syst, 2021 Huth A, Duddu R, Smith B.
europepmc +1 more source
Mechanical Chondrocyte Damage Thresholds
ASME 2012 Summer Bioengineering Conference, Parts A and B, 2012 Chondrocyte content in articular cartilage is very low. Only 2% to 5% of the tissue volume consists of chondrocytes [1]. Yet, these cells are responsible for maintenance of the tissue. Hence, the loss of chondrocytes that is often occurring at an early stage of cartilage degeneration is detrimental to articular cartilage.
Turnhout, van, M.C. +3 more
openaire +3 more sources
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Fatigue behavior of adhesively bonded joints [PDF]
The fatigue damage mechanism of composite to composite adhesively bonded joints was characterized. The mechanics of the possible modes of fatigue damage propagation in these joints when subjected to constant amplitude cyclic mechanical loading were ...
Mall, S.
core +1 more source
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source