Results 101 to 110 of about 436,032 (358)

Damage Mechanics of Biological Tissues in Relation to Viscoelasticity. [PDF]

J Biomech Eng, 2023
Ateshian GA, Kroupa KR, Petersen CA, Zimmerman BK, Maas SA, Weiss JA.   +5 more
europepmc   +1 more source

Mechanism of DNA damage tolerance

World Journal of Biological Chemistry, 2015
DNA damage may compromise genome integrity and lead to cell death. Cells have evolved a variety of processes to respond to DNA damage including damage repair and tolerance mechanisms, as well as damage checkpoints. The DNA damage tolerance (DDT) pathway promotes the bypass of single-stranded DNA lesions encountered by DNA polymerases during DNA ...
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Damage mechanics - based creep - fatigue analysis of combustion chamber for satellite's bipropellant thruster

Nihon Kikai Gakkai ronbunshu, 2016
Creep - fatigue analyses based on the concept of continuum damage mechanics were conducted for the combustion chamber used in a satellite's bipropellant thruster.
Tadashi MASUOKA, Yutaka TOI, Hirohide IKEDA   +2 more
doaj   +1 more source

A Phase-Field Approach to Continuum Damage Mechanics. [PDF]

Materials (Basel), 2022
Morro A.
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Development of a damage rheological model and its application in the analysis of mechanical properties of jointed rock masses

Energy Science & Engineering, 2019
Fossil fuel resources (eg, coal, oil, and natural gas) exist in underground reservoirs, where discontinuities are widespread and influence the stability of rock structures.
Wendong Yang, Guangyu Luo, Kang Duan, Wenjun Jing, Lianzhen Zhang, Shugang Wang, Yan Zhao   +6 more
doaj   +1 more source

Parametric Damage Mechanics Empowering Structural Health Monitoring of 3D Woven Composites. [PDF]

Sensors (Basel), 2023
Jacot M, Champaney V, Chinesta F, Cortial J.   +3 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Finite element modeling of meniscal tears using continuum damage mechanics and digital image correlation. [PDF]

Sci Rep, 2023
Nesbitt DQ, Burruel DE, Henderson BS, Lujan TJ.   +3 more
europepmc   +1 more source