Results 91 to 100 of about 2,149,929 (236)

Damage mechanics - based creep - fatigue analysis of combustion chamber for satellite's bipropellant thruster

open access: yesNihon Kikai Gakkai ronbunshu, 2016
Creep - fatigue analyses based on the concept of continuum damage mechanics were conducted for the combustion chamber used in a satellite's bipropellant thruster.
Tadashi MASUOKA   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Development of a damage rheological model and its application in the analysis of mechanical properties of jointed rock masses

open access: yesEnergy Science & Engineering, 2019
Fossil fuel resources (eg, coal, oil, and natural gas) exist in underground reservoirs, where discontinuities are widespread and influence the stability of rock structures.
Wendong Yang   +6 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

On an isotropic damage mechanics model for ductile materials

open access: yes, 2022
S.325-346A new model for combined elastoplasticity and damage is proposed. The model is based on the maximum dissipation principle and implements a strong coupling between plasticity and damage.
Hesebeck, O.
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Avaliação de deflexões em estruturas de concretoarmado utilizando mecânica do dano

open access: yesRevista IBRACON de Estruturas e Materiais
Este trabalho visa apresentar uma contribuição sobre uma proposta de abordagem para o cálculo de deslocamentos em estruturas de concreto armado em regime de serviço, sendo restrito o estudo ao caso de concretos C20 a C35.
J. J. C. Pituba, R. G. Delalibera
doaj   +1 more source

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