Results 71 to 80 of about 436,032 (358)

MECHANISM OF ALCOHOLIC TESTICULAR DAMAGE

The Japanese Journal of Urology, 1992
To observe the mechanism of alcoholic testicular damage, in a previous experiment we used weanling male SD rats aged 45 days, weighing about 200 g, and fed a liquid diet (Lieber's) containing 5% ethanol. The latter accounted for 36% of total caloric intake for 7 weeks, but did not result in testicular atrophy.
T, Shirai, I, Ikemoto
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Modelling the Damage of Structural Components with Macrostructure Defects

Metals, 2019
The article presents a numerical analysis of the process of damage of structural steel, the scope of which encompassed the estimation of the time to failure of a structural component.
Paweł Grzegorz Kossakowski
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Fundamental problems in blast-induced damage and protection of naval vessels: a state-of-the-art review

Zhongguo Jianchuan Yanjiu
Large ships and submarines are the main equipment and mobile platforms supporting three-dimensional naval space operations. However, with the increasing damage power and strike accuracy of warheads, plus the diversity of destroying elements, their living
Ying LI, Zhipeng DU, Ganchao CHEN, Shiping WANG, Hailiang HOU, Xiaobin LI, Pan ZHANG, Lunping ZHANG, Xiangshao KONG, Haitao LI, Jun GUO, Shujian YAO, Zhikai WANG, Caiyu YIN   +13 more
doaj   +1 more source

Evaluation of fatigue life of polycrystalline structural alloys

MATEC Web of Conferences, 2018
A mathematical model describing the processes of elastoplastic deformation and damage accumulation under low-cycle loading has been developed, based on the viewpoint of mechanics of damaged media (MDM). The MDM model consists of three interrelated parts:
Volkov Ivan A., Igumnov Leonid A., Ipatov Aleksandr A.   +2 more
doaj   +1 more source

Progressive failure methodologies for predicting residual strength and life of laminated composites [PDF]

Two progressive failure methodologies currently under development by the Mechanics of Materials Branch at NASA Langley Research Center are discussed. The damage tolerance/fail safety methodology developed by O'Brien is an engineering approach to ensuring
Allen, David H., Harris, Charles E., Obrien, T. Kevin   +2 more
core   +1 more source

Modelling of impact damage and permanent indentation on laminate composite plate [PDF]

, 2010
This paper deals with impact damage and permanent indentation modelling. A model enabling the formation of damages developing during a low velocity / low energy impact test on laminate composite panels has been elaborated.
Barrau, Jean-Jacques, Bouvet, Christophe, Rivallant, Samuel   +2 more
core   +1 more source

Mechanisms of Toxic Damage to Spermatogenesis [PDF]

Journal of the National Cancer Institute Monographs, 2005
Azoospermia and long-lasting testicular atrophy are common adverse consequences of cancer treatment. Chemotherapeutic agents may disrupt spermatogenesis by targeting various testicular cell types (Leydig cells, Sertoli cells, and germ cells) and by activating numerous molecular pathways involved in germ cell life-and-death decision making.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source