Results 71 to 80 of about 60,909 (219)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

An Entropy Based Low-Cycle Fatigue Life Prediction Model for Solder Materials

Entropy, 2017
Fatigue damage is an irreversible progression which can be represented by the entropy increase, and it is well known that the second law of thermodynamics can describe an irreversible process.
Jundong Wang, Yao Yao
doaj   +1 more source

Parametric Damage Mechanics Empowering Structural Health Monitoring of 3D Woven Composites. [PDF]

Sensors (Basel), 2023
Jacot M, Champaney V, Chinesta F, Cortial J.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Intelligent Models of Wear-Fatigue Damage and Fracture Mechanics

Механика машин, механизмов и материалов
Artificial intelligence technologies are considered in comparison with mathematical modeling using the examples of a number of critical purpose technical systems studied in tribo-fatigue.
Sergei S. Sherbakov
doaj   +1 more source

Damage mechanics - based creep - fatigue analysis of combustion chamber for satellite's bipropellant thruster

Nihon Kikai Gakkai ronbunshu, 2016
Creep - fatigue analyses based on the concept of continuum damage mechanics were conducted for the combustion chamber used in a satellite's bipropellant thruster.
Tadashi MASUOKA, Yutaka TOI, Hirohide IKEDA   +2 more
doaj   +1 more source

Finite element modeling of meniscal tears using continuum damage mechanics and digital image correlation. [PDF]

Sci Rep, 2023
Nesbitt DQ, Burruel DE, Henderson BS, Lujan TJ.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Development of a damage rheological model and its application in the analysis of mechanical properties of jointed rock masses

Energy Science & Engineering, 2019
Fossil fuel resources (eg, coal, oil, and natural gas) exist in underground reservoirs, where discontinuities are widespread and influence the stability of rock structures.
Wendong Yang, Guangyu Luo, Kang Duan, Wenjun Jing, Lianzhen Zhang, Shugang Wang, Yan Zhao   +6 more
doaj   +1 more source

Cortical bone continuum damage mechanics constitutive model with stress triaxiality criterion to predict fracture initiation and pattern. [PDF]

Front Bioeng Biotechnol, 2022
Cronin DS, Watson B, Khor F, Gierczycka D, Malcolm S.   +4 more
europepmc   +1 more source